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The afferent fiber delivers information regarding osmolality, glucose level, and lipid level in the portal vein to the central nervous system (CNS). In contrast, the efferent fiber is crucial in the regulation of metabolism, blood flow, and bile secretion. Furthermore, liver innervation has been associated with hepatic fibrosis, regeneration, and circadian rhythm. Knowledge of these mechanisms can be applied for potential liver disease treatment.<\/jats:p>","DOI":"10.1111\/hepr.12760","type":"journal-article","created":{"date-parts":[[2016,6,7]],"date-time":"2016-06-07T10:58:20Z","timestamp":1465297100000},"page":"160-165","source":"Crossref","is-referenced-by-count":133,"title":["Autonomic Nervous System and the Liver"],"prefix":"10.1111","volume":"47","author":[{"given":"Kei","family":"Mizuno","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Yamagata University Faculty of Medicine"},{"name":"CREST  Yamagata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiyuki","family":"Ueno","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Yamagata University Faculty of Medicine"},{"name":"CREST  Yamagata 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