{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T05:52:36Z","timestamp":1761630756325},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,7,19]],"date-time":"2016-07-19T00:00:00Z","timestamp":1468886400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Liver transplantation is the only curative treatment for hepatorenal syndrome (HRS); however, the influence of HRS on the patient and renal outcome after living donor liver transplantation (LDLT) is still unclear. The aim of the present study was to evaluate the influence of HRS on the outcome of LDLT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analyzed 357 consecutive adult patients who underwent primary LDLT between January 2005 and March 2013 at Kyoto University Hospital. The outcome of the patients with HRS was compared with those without HRS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 29 patients (8%) were diagnosed as HRS (Group\u2010HRS) preoperatively, and the other 328 patients (92%) were not diagnosed as HRS (Group\u2010Non\u2010HRS). Group\u2010HRS showed a significantly lower preoperative estimated glomerular filtration rate (22.1 vs 78.3\u00a0mL\/min\/1.73m<jats:sup>2<\/jats:sup>, <jats:italic>P<\/jats:italic>\u2009&lt;\u00a00.001) and higher Child\u2013Pugh\u2013Turcotte score (13 vs 10, <jats:italic>P<\/jats:italic>\u2009&lt;\u00a00.001) than Group\u2010non\u2010HRS. After a median follow up of 60\u00a0months, the 1\u2010, 3\u2010 and 5\u2010year recipients' survival were 60.7%, 57.1% and 57.1% in Group\u2010HRS, and 83.7%, 79.4% and 76.2% in Group\u2010Non\u2010HRS, respectively (<jats:italic>P<\/jats:italic>\u2009=\u20090.030). Concomitant HRS significantly elongated postoperative hospital stays (75 vs 50\u00a0days, <jats:italic>P<\/jats:italic>\u2009=\u20090.003), as well as predisposed patients to higher in\u2010hospital mortality (41% vs 18%, <jats:italic>P<\/jats:italic>\u2009=\u20090.005). Multivariate analysis showed that preoperative renal dysfunction (estimated glomerular filtration rate on admission &lt;40\u00a0mL\/min\/1.73m<jats:sup>2<\/jats:sup>, OR 2.106, <jats:italic>P<\/jats:italic>\u2009=\u20090.03) was an independent risk factor for 1\u2010year recipients' survival after LDLT, in addition to donor age \u226538\u00a0years (OR 3.114, <jats:italic>P<\/jats:italic>\u2009&lt;\u00a00.001), Child\u2013Pugh\u2013Turcotte score \u226513 (OR 2.929, <jats:italic>P<\/jats:italic>\u2009&lt;\u00a00.001) and left lobe graft (OR 2.225, <jats:italic>P<\/jats:italic>\u2009=\u20090.004).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Coincidence of HRS is associated with significantly worse outcome after LDLT, especially in the early post\u2010transplant period.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.12764","type":"journal-article","created":{"date-parts":[[2016,6,20]],"date-time":"2016-06-20T17:22:46Z","timestamp":1466443366000},"page":"425-434","source":"Crossref","is-referenced-by-count":11,"title":["Influence of hepatorenal syndrome on outcome of living donor liver transplantation: A single\u2010center experience in 357 patients"],"prefix":"10.1111","volume":"47","author":[{"given":"Yusuke","family":"Okamura","sequence":"first","affiliation":[{"name":"Division of Hepato\u2010Biliary\u2010Pancreatic Surgery and Transplantation, Department of Surgery, Graduate School of Medicine Kyoto University  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichiro","family":"Hata","sequence":"additional","affiliation":[{"name":"Division of Hepato\u2010Biliary\u2010Pancreatic Surgery and Transplantation, Department of Surgery, Graduate School of Medicine Kyoto University  Kyoto 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