{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T13:08:46Z","timestamp":1713445726774},"reference-count":35,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,12,5]],"date-time":"2016-12-05T00:00:00Z","timestamp":1480896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Insulin resistance and type 2 diabetes mellitus (T2DM) contribute to the progression of non\u2010alcoholic fatty liver disease (NAFLD). However, the relationship between glucose metabolic factors and the histological severity in NAFLD patients before development of T2DM is not well known.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In 103 biopsy\u2010proven NAFLD patients (68 men and 35 women) with hemoglobin A1c of &lt;6.5% and fasting blood glucose of &lt;126\u00a0mg\/dL, we investigated whether glucose metabolic factors influenced the severity of hepatic fibrosis without prior known T2DM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Female gender, age, serum aspartate aminotransferase, the aspartate aminotransferase\/alanine aminotransferase ratio, fasting immunoreactive insulin (f\u2010IRI), homeostasis model assessment \u2013 insulin resistance, hemoglobin A1c, hyaluronic acid, and type IV collagen 7\u00a0s were significantly higher, and 1,5\u2010anhydroglucitol was significantly lower, in the fibrosis stage F3 group than in the F0\u20132 group. Multiple logistic regression analysis showed that only f\u2010IRI (<jats:italic>P<\/jats:italic>\u2009=\u20090.006; odds ratio, 1.15151; 95% confidence interval, 1.04198\u20131.27254) was significantly indicated as a predictive factor for F3. As determined by both forward and backward stepwise selection analyses to optimize the model, f\u2010IRI (<jats:italic>P<\/jats:italic>\u2009=\u20090001; odds ratio, 1.16788) remained an independent predictive factor for F3. To discriminate the F3 group from the F0\u20132 group, the area under the receiver operating characteristic curves showed that fasting insulin was 0.7219, and the best cut\u2010off value of f\u2010IRI was 13.2\u00a0\u03bcU\/mL in the receiver operating characteristic curve analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>High fasting insulin concentrations may be a pivotal glucose metabolic predictor for the severity of hepatic fibrosis beyond the glycemic status in NAFLD patients before development of T2DM.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.12832","type":"journal-article","created":{"date-parts":[[2016,12,5]],"date-time":"2016-12-05T05:55:03Z","timestamp":1480917303000},"page":"983-990","source":"Crossref","is-referenced-by-count":6,"title":["High fasting insulin concentrations may be a pivotal predictor for the severity of hepatic fibrosis beyond the glycemic status in non\u2010alcoholic fatty liver disease patients before development of 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