{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T09:14:00Z","timestamp":1707902040444},"reference-count":43,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,1,17]],"date-time":"2017-01-17T00:00:00Z","timestamp":1484611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>The development of direct\u2010acting oral agents has dramatically changed the treatment strategy of hepatitis C virus (HCV) infection. Here we aimed to reveal the efficacy and safety of daclatasvir (DCV) and asunaprevir (ASV) for recurrent HCV genotype 1 infection after liver transplantation (LT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective study was undertaken on nine patients who underwent a 24\u2010week DCV\/ASV treatment regimen for recurrent HCV genotype 1 infection. Five of the patients were men; four had failed treatment with pegylated interferon (Peg\u2010IFN)\/ribavirin, two had failed simeprevir\/Peg\u2010IFN\/ribavirin, one had the resistance\u2010associated variant Y93H in the NS5A region, and one underwent maintenance dialysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median time to treatment initiation following LT was 70\u2009months. Of the nine patients treated with DCV\/ASV, eight (88.9%) achieved a sustained viral response 12\u00a0weeks after completion of therapy (SVR12). The patient with virologic failure had failed simeprevir\/Peg\u2010interferon\/ribavirin therapy 4\u00a0months before undergoing the DCV\/ASV treatment regimen. In addition, a resistance\u2010associated variant D168E in the NS3 region was detected in the patient after discontinuation of the DCV\/ASV regimen. The trough level of tacrolimus tended to decrease, and renal function showed no significant changes during treatment. Adverse events occurred in two patients (22.2%), but no severe adverse events occurred during treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The DCV\/ASV regimen was well tolerated, resulting in high rates of sustained viral response 12\u00a0weeks after completion of therapy for LT patients with recurrent HCV genotype 1 infection.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.12853","type":"journal-article","created":{"date-parts":[[2016,12,21]],"date-time":"2016-12-21T22:59:07Z","timestamp":1482361147000},"page":"1147-1154","source":"Crossref","is-referenced-by-count":2,"title":["Outcomes of treatment with daclatasvir and asunaprevir for recurrent hepatitis C after liver transplantation"],"prefix":"10.1111","volume":"47","author":[{"given":"Masaki","family":"Honda","sequence":"first","affiliation":[{"name":"Departments of Transplantation\/Pediatric Surgery"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiko","family":"Sugawara","sequence":"additional","affiliation":[{"name":"Departments of Transplantation\/Pediatric Surgery"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takehisa","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Postgraduate School of Life Science, Kumamoto University  Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masakuni","family":"Tateyama","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Postgraduate School of Life Science, Kumamoto University  Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motohiko","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Postgraduate School of Life Science, Kumamoto University  Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koushi","family":"Uchida","sequence":"additional","affiliation":[{"name":"Departments of Transplantation\/Pediatric Surgery"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiichi","family":"Kawabata","sequence":"additional","affiliation":[{"name":"Departments of Transplantation\/Pediatric Surgery"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daiki","family":"Yoshii","sequence":"additional","affiliation":[{"name":"Departments of Transplantation\/Pediatric Surgery"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kouhei","family":"Miura","sequence":"additional","affiliation":[{"name":"Departments of Transplantation\/Pediatric Surgery"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaori","family":"Isono","sequence":"additional","affiliation":[{"name":"Departments of Transplantation\/Pediatric Surgery"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shintaro","family":"Hayashida","sequence":"additional","affiliation":[{"name":"Departments of Transplantation\/Pediatric Surgery"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Ohya","sequence":"additional","affiliation":[{"name":"Departments of Transplantation\/Pediatric Surgery"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidekazu","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Departments of Transplantation\/Pediatric Surgery"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaka","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Postgraduate School of Life Science, Kumamoto University  Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukihiro","family":"Inomata","sequence":"additional","affiliation":[{"name":"Departments of Transplantation\/Pediatric Surgery"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,1,17]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2000.17924"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(92)91129-R"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.21784"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)06102-5"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa020047"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1012912"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1010494"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.12272"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00534-007-1295-5"},{"key":"e_1_2_5_11_1","article-title":"Antiviral treatment for hepatitis C virus infection after liver transplantation","volume":"2010","author":"Sugawara Y","year":"2010","journal-title":"Hepat Res Treat"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/tri.12329"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13027"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24724"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61059-X"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27113"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.12474"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0012.2010.01322.x"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1408921"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.24126"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.05.010"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.12509"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.12602"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000000860"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-016-9744-3"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/tri.12653"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2003.01780.x"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1053\/jlts.2003.50211"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.12103"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13765"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1316366"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.06.002"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12524"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000001126"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-016-1174-4"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-016-1162-8"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.12553"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-016-1225-x"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60494-3"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.12673"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1104430"},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27559"},{"key":"e_1_2_5_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27972"},{"key":"e_1_2_5_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00349-9"}],"container-title":["Hepatology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhepr.12853","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hepr.12853","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T15:08:42Z","timestamp":1695568122000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hepr.12853"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,17]]},"references-count":43,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["10.1111\/hepr.12853"],"URL":"https:\/\/doi.org\/10.1111\/hepr.12853","archive":["Portico"],"relation":{},"ISSN":["1386-6346","1872-034X"],"issn-type":[{"value":"1386-6346","type":"print"},{"value":"1872-034X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,17]]}}}