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Non\u2010alcoholic steatohepatitis (NASH), a severe form of NAFLD, can lead to hepatocellular carcinoma and hepatic failure. Non\u2010alcoholic steatohepatitis can be called \u201cdiabetic hepatopathy\u201d. There are no established pharmacotherapies for NAFLD\/NASH patients with T2DM. Although metformin is established as the first\u2010line therapy for T2DM, given its relative safety and beneficial effects on glycosylated hemoglobin, weight, and cardiovascular mortality, this agent is not recommended as specific therapy for NASH\/NAFLD due to lack of clinical evidence. The effects of pioglitazone on NASH histology with T2DM have been extensively proved, but several concerns exist, such as body weight gain, fluid retention, cancer incidence, and bone fracture. In recent years, novel antidiabetic medications have been approved for T2DM, such as glucagon\u2010like peptide 1 receptor agonists, dipeptidyl peptidase 4 inhibitors, and sodium\/glucose cotransporter 2 inhibitors. A key clinical question for hepatologists is what kinds of antidiabetic medications are the most appropriate for the treatment of NAFLD accompanied by T2DM, to prevent progression of hepatic fibrosis resulting in HCC\/liver\u2010related mortality without increased risk of cardiovascular events. This review focuses on novel antidiabetic agents and future perspectives on the treatment of NAFLD\/NASH with T2DM.<\/jats:p>","DOI":"10.1111\/hepr.12856","type":"journal-article","created":{"date-parts":[[2016,12,26]],"date-time":"2016-12-26T07:16:50Z","timestamp":1482736610000},"page":"266-280","source":"Crossref","is-referenced-by-count":54,"title":["Novel antidiabetic medications for non\u2010alcoholic fatty liver disease with type 2 diabetes mellitus"],"prefix":"10.1111","volume":"47","author":[{"given":"Yoshio","family":"Sumida","sequence":"first","affiliation":[{"name":"Division of Hepatology and Pancreatology, Department of Internal Medicine Aichi Medical University  Nagakute Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuya","family":"Seko","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Kyoto Prefectural University of Medicine  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masashi","family":"Yoneda","sequence":"additional","affiliation":[{"name":"Division of Hepatology and Pancreatology, Department of Internal Medicine Aichi Medical University  Nagakute Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Japan Study Group of NAFLD (JSG\u2010NAFLD)","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,2,13]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2040-1124.2010.00019.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28431"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.25762"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-015-1050-7"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.11.004"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-013-0911-1"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.11.039"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.06.061"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0907929"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61933-4"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.1437"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-142-1-200501040-00110"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa060326"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.7326\/M15-1774"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.7996"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.5"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2012.719926"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v22.i27.6100"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000003527"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.5"},{"key":"e_1_2_5_22_1","unstructured":"Japan Diabetes Clinical Data Management (JDDM) Study Group.Basic Statistical Data in 2013.2015; Available at:http:\/\/jddm.jp\/index.html. 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