{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T12:35:27Z","timestamp":1758630927672},"reference-count":27,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,2,19]],"date-time":"2017-02-19T00:00:00Z","timestamp":1487462400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>We examined the feasibility of the aspartate transaminase (AST)\u2013platelet ratio index (APRI) and Fibrosis\u20104 (FIB4) score, which are well\u2010established markers for liver fibrosis, as indicators for monitoring esophageal varices in patients who were co\u2010infected with HIV and hepatitis C virus (HCV) due to contaminated blood products for hemophilia in Japan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010three HIV\/HCV co\u2010infected patients were enrolled. All were hemophilic men (median age 41\u00a0years; range, 29\u201366\u00a0years). We analyzed the correlations between fibrosis indices (APRI, FIB4) and various liver function tests, fibrosis markers, liver stiffness measured by acoustic radiation force impulse elastography, and the findings of gastrointestinal endoscopy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both APRI and FIB4 were well correlated with several of the factors related to liver fibrosis and the existence of esophageal varices in the patients. The cut\u2010off values for detecting esophageal varices estimated as the area under the receiver operating characteristic curve were 0.85 for APRI and 1.85 for FIB4.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In patients co\u2010infected with HIV\/HCV due to contaminated blood products for hemophilia, APRI and FIB4 are effective for monitoring esophageal varices, even among patients who are apparently doing well with good liver function as Child\u2013Pugh grade A.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.12866","type":"journal-article","created":{"date-parts":[[2017,1,28]],"date-time":"2017-01-28T10:07:06Z","timestamp":1485598026000},"page":"1282-1288","source":"Crossref","is-referenced-by-count":8,"title":["Aspartate transaminase\u2013platelet ratio and Fibrosis\u20104 indices as effective markers for monitoring esophageal varices in HIV\/hepatitis C virus co\u2010infected patients due to contaminated blood products for hemophilia"],"prefix":"10.1111","volume":"47","author":[{"given":"Koji","family":"Natsuda","sequence":"first","affiliation":[{"name":"Department of Surgery Nagasaki University Graduate School of Biomedical Sciences  Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuhisa","family":"Takatsuki","sequence":"additional","affiliation":[{"name":"Department of Surgery Nagasaki University Graduate School of Biomedical Sciences  Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Surgery Nagasaki University Graduate School of Biomedical Sciences  Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiko","family":"Soyama","sequence":"additional","affiliation":[{"name":"Department of Surgery Nagasaki University Graduate School of Biomedical Sciences  Nagasaki 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