{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T23:49:13Z","timestamp":1790293753947,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2017,4,27]],"date-time":"2017-04-27T00:00:00Z","timestamp":1493251200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>The histological features of clinically chronic autoimmune hepatitis (AIH) have been well established, with interface hepatitis and plasma cell infiltration as hallmark lesions, however, the immunoserological and histological features of recent\u2010onset and acute AIH remain undefined. The goal of this study was to define the immunoserological and histological differences between AIH with acute presentation and chronic AIH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010two consecutive patients with well\u2010characterized AIH who had undergone a liver biopsy were identified at our institution. These patients were divided into two groups. Sixteen patients whose liver dysfunction had persisted for at least 12\u00a0months were defined as chronic AIH (C\u2010AIH) patients, and 16 patients whose liver dysfunction had been within normal limits for &gt;12\u00a0months previously, and had only recently been found to have abnormal function for the first time, were defined as AIH with acute presentation (AIH\u2010a) patients. Various biological and histological characteristics were compared between these two patient groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No significant differences were found between the groups for age, body mass index, serum levels of total bilirubin, transaminase, alkaline phosphatase, prothrombin activity, immunoglobulin, titers of antinuclear antibody, or diagnostic scores between the groups. Histologically, there was no significant difference in the degree of interface hepatitis, plasma cell infiltration, or centrilobular necrosis between AIH\u2010a and C\u2010AIH patients. However, histological active findings such as activity, lobular inflammation, rosette formation, spotty necrosis, seroid\u2010laden macrophages, and single cell necrosis were significantly more frequent in AIH\u2010a patients, whereas portal fibrosis was significantly more frequent in C\u2010AIH patients. Only one case among the 16 AIH\u2010a patients was confirmed as acute AIH, showing massive centrilobular necrosis with a mild degree of portal inflammation and interface hepatitis. All patients with AIH\u2010a and C\u2010AIH responded well to corticosteroid or ursodeoxycholic acid treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with AIH\u2010a could not be distinguished from C\u2010AIH patients clinically or immunoserologically. Based on the histopathological findings of the liver, almost all cases of AIH\u2010a might be exacerbations of non\u2010symptomatic pre\u2010existing C\u2010AIH.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.12875","type":"journal-article","created":{"date-parts":[[2017,2,21]],"date-time":"2017-02-21T15:54:56Z","timestamp":1487692496000},"page":"1375-1382","source":"Crossref","is-referenced-by-count":18,"title":["Immunoserological and histological differences between autoimmune hepatitis with acute presentation and chronic autoimmune hepatitis"],"prefix":"10.1111","volume":"47","author":[{"given":"Kazufumi","family":"Dohmen","sequence":"first","affiliation":[{"name":"Internal Medicine Chihaya Hospital  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirofumi","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Internal Medicine Chihaya Hospital  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masatora","family":"Haruno","sequence":"additional","affiliation":[{"name":"Internal Medicine Chihaya Hospital  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichi","family":"Aishima","sequence":"additional","affiliation":[{"name":"Pathology and Microbiology Saga University  Saga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,4,27]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-62-3-425"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1040641"},{"key":"e_1_2_5_4_1","first-page":"75","volume-title":"Autoimmune Liver Diseases","author":"Batts KP","year":"1991"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(05)80279-X"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1089-3261(02)00022-3"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0676.1984.tb00954.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2005.029348"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199506000-00010"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1386-6346(02)00274-7"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(99)80297-9"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.198.1.8539386"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840180435"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.12639"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-008-2254-x"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-010-0316-3"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(94)80251-3"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2006.10.011"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2007.03.019"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1872-034X.2011.00808.x"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-012-0624-x"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-012-2445-4"},{"key":"e_1_2_5_23_1","first-page":"51","article-title":"Autoimmune hepatitis with acute presentation in Japan","volume":"42","author":"Miyake Y","year":"2010","journal-title":"Dig Dis Sci"}],"container-title":["Hepatology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhepr.12875","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hepr.12875","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T10:18:45Z","timestamp":1695982725000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hepr.12875"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,27]]},"references-count":22,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.1111\/hepr.12875"],"URL":"https:\/\/doi.org\/10.1111\/hepr.12875","archive":["Portico"],"relation":{},"ISSN":["1386-6346","1872-034X"],"issn-type":[{"value":"1386-6346","type":"print"},{"value":"1872-034X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,27]]}}}