{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:18:30Z","timestamp":1762867110703},"reference-count":47,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2017,5,30]],"date-time":"2017-05-30T00:00:00Z","timestamp":1496102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>From a pharmacokinetic viewpoint, the use of ombitasvir\/paritaprevir\/ritonavir, one of the standards of care for genotype 1b chronic hepatitis C in Japan, could be possible in patients with impaired renal function. The aim of this study was to assess the efficacy and safety of this combination that have not yet been addressed in patients undergoing dialysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective, multicenter study evaluated the outcome of 12\u2010week ombitasvir (non\u2010structural protein [NS]5A inhibitor)\/paritaprevir (NS3\/4A protease inhibitor)\/ritonavir combination therapy for dialysis patients. The primary end\u2010point was sustained virologic response 12\u00a0weeks after therapy (SVR12).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The subjects were 31 patients with a median age of 64\u00a0years (range, 49\u201385\u00a0years), including 10 cirrhotic patients. All of the 31 patients had an estimated glomerular filtration rate level\u00a0&lt;15\u00a0mL\/min\/1.73\u00a0m<jats:sup>2<\/jats:sup>, defined as end\u2010stage renal disease (ESRD). Pre\u2010existing resistance\u2010associated substitutions at position L31 and Y93 of the NS5A region were detected in 0% and 3.6% (1\/28), respectively. The rates of rapid virologic response, end\u2010of\u2010treatment response, and SVR12 were 93.5% (29\/31), 100% (31\/31), and 96.8% (30\/31), respectively. The incidence of adverse events was 35.5% (11\/31). Of the 11 patients, one discontinued the treatment due to erythema multiforme and thereafter relapsed. The most frequent adverse event was pruritus (6.5%; 2\/31).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The present study suggests that ombitasvir\/paritaprevir\/ritonavir combination therapy is effective and safe for genotype 1b chronic hepatitis C patients undergoing dialysis due to ESRD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.12910","type":"journal-article","created":{"date-parts":[[2017,4,30]],"date-time":"2017-04-30T14:53:35Z","timestamp":1493564015000},"page":"1429-1437","source":"Crossref","is-referenced-by-count":40,"title":["Efficacy and safety of ombitasvir\/paritaprevir\/ritonavir in dialysis patients with genotype 1b chronic hepatitis C"],"prefix":"10.1111","volume":"47","author":[{"given":"Masanori","family":"Atsukawa","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine Nippon Medical School  Tokyo Japan"},{"name":"Department of Internal Medicine, Division of 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