{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T17:34:21Z","timestamp":1792863261550,"version":"4.5.0"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,8,7]],"date-time":"2017-08-07T00:00:00Z","timestamp":1502064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Nihon Pharmaceutical Co., Ltd."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Portal vein thrombosis (PVT) is one of the most critical disorders in liver disease patients. These patients have the imbalance of coagulation and coagulation inhibition resulting from decreased levels of coagulation inhibitory factors, such as protein C, protein S, and antithrombin III (AT\u2010III). We designed this randomized, double\u2010blind, placebo\u2010controlled trial comparing the safety and efficacy of AT\u2010III for PVT in liver disease patients with those who received no treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eligible patients were diagnosed with the association of thrombus, without tumor thrombus, and thrombus in more than 50% of the cross\u2010sectional lumen of the portal vein. Patients with 70% or less serum level of AT\u2010III were included. The study drug was given up to three times in a 5\u2010day consecutive infusion interval if the thrombus decreased in size. Efficacy was evaluated by contrast enhanced computed tomography using a five\u2010grade scale (complete response, partial response, slight response, no response, and progression). From October 2014 through to March 2016, 36 patients were randomly assigned to the AT\u2010III group and 37 patients to the placebo group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The proportion of patients with complete response or partial response of PVT was significantly higher in the AT\u2010III group (55.6%; 20\/36 patients; 95% confidence interval, 38.1\u201372.1) than in the placebo group (19.4%; 7\/36 patients, 95% confidence interval, 8.2\u201336.0) (<jats:italic>P<\/jats:italic>\u2009=\u20090.003). The overall incidence of adverse events and adverse drug reactions did not differ significantly between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Antithrombin III is one of the essential therapies for patients with PVT in cases with lower concentration levels of AT\u2010III.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.12934","type":"journal-article","created":{"date-parts":[[2017,6,30]],"date-time":"2017-06-30T17:26:38Z","timestamp":1498843598000},"source":"Crossref","is-referenced-by-count":49,"title":["Antithrombin III for portal vein thrombosis in patients with liver disease: A randomized, double\u2010blind, controlled trial"],"prefix":"10.1111","volume":"48","author":[{"given":"Hisashi","family":"Hidaka","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Internal Medicine Kitasato University School of Medicine  Sagamihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigehiro","family":"Kokubu","sequence":"additional","affiliation":[{"name":"Institute for Liver Disease Minimal Invasive Treatment Shinyurigaoka General Hospital  Kawasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Sapporo Kosei General Hospital  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Katsushima","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology National Hospital Organization Kyoto Medical Center  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Namiki","family":"Izumi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Musashino Red Cross Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takumi","family":"Igura","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Ikeda Municipal Hospital  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shingo","family":"Asahara","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Chiba Tokushukai Hospital  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Notsumata","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Fukui\u2010ken Saiseikai Hospital  Fukui Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukio","family":"Osaki","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Osaka Red Cross Hospital  Osaka 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