{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T12:39:18Z","timestamp":1775911158031,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,10,18]],"date-time":"2017-10-18T00:00:00Z","timestamp":1508284800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>We examined the prognosis of liver cirrhosis (LC) patients with and without portal hypertension (PHT) and muscle volume loss (MVL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From 2006 to 2016, 346 LC outpatients (PHT\/non\u2010PHT\u2009=\u2009173\/173) were enrolled (median age, 69\u00a0years; men\u00a0\/\u00a0women,\u00a0204\/142; Child\u2013Pugh A\u00a0\/\u00a0B,\u00a0230\/116; and presence of MVL 15.6% in each group) after propensity matching, following exclusion of those with hepatocellular carcinoma (HCC) beyond the Milan criteria and Child\u2013Pugh C. Portal hypertension was defined as positive for significant esophagogastric varices; MVL was diagnosed based on a previously reported index using CT imaging. Overall survival rate (OSR) was evaluated from the viewpoints of PHT and MVL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were no significant differences in clinical background (age, gender, etiology, presence of HCC [within Milan criteria], or Child\u2013Pugh class) between the groups. Although there was no significant difference regarding OSR between patients with and without MVL in the non\u2010PHT group (<jats:italic>P<\/jats:italic>\u2009=\u20090.076, Holm's method), the OSR of patients with MVL in the PHT group was lower compared to those without MVL in both groups (<jats:italic>P<\/jats:italic>\u2009=\u20090.017 and <jats:italic>P<\/jats:italic>\u2009=\u20090.012, respectively, Holm's method). As a result, the OSR of patients with MVL (<jats:italic>n<\/jats:italic>\u2009=\u200954) was lower than the other patients (<jats:italic>n<\/jats:italic>\u2009=\u2009292) (3\u2010 and 5\u2010year OSR, 69.0% vs. 86.4% and 35.8% vs. 74.1%, respectively; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Multivariate Cox hazard analysis showed that positive for HCC (hazard ratio [HR], 2.028; 95% confidence interval [CI], 1.189\u20133.460; <jats:italic>P<\/jats:italic>\u2009=\u20090.009) and positive for MVL (HR, 2.768; 95% CI, 1.575\u20134.863; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) were significant independent prognostic factors for death.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Muscle volume loss and HCC, but not PHT, were found to be independent prognostic factors for death in LC patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.12984","type":"journal-article","created":{"date-parts":[[2017,9,21]],"date-time":"2017-09-21T04:33:02Z","timestamp":1505968382000},"source":"Crossref","is-referenced-by-count":16,"title":["Muscle volume loss a prognostic factor for death in liver cirrhosis patients and special relationship to portal hypertension"],"prefix":"10.1111","volume":"48","author":[{"given":"Atsushi","family":"Hiraoka","sequence":"first","affiliation":[{"name":"Gastroenterology Center Ehime Prefectural Central Hospital  Matsuyama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shogo","family":"Kitahata","sequence":"additional","affiliation":[{"name":"Gastroenterology Center Ehime Prefectural Central Hospital  Matsuyama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirofumi","family":"Izumoto","sequence":"additional","affiliation":[{"name":"Gastroenterology Center Ehime Prefectural Central Hospital  Matsuyama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidetaro","family":"Ueki","sequence":"additional","affiliation":[{"name":"Gastroenterology Center Ehime Prefectural Central Hospital  Matsuyama 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