{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T09:24:47Z","timestamp":1745227487194},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,12,20]],"date-time":"2017-12-20T00:00:00Z","timestamp":1513728000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\"><jats:italic>Wisteria floribunda<\/jats:italic><\/jats:styled-content> agglutinin\u2010positive Mac\u20102 binding protein (WFA<jats:sup>+<\/jats:sup>\u2010M2BP) is a novel serum marker of hepatic fibrosis in adults with chronic hepatitis C. However, it remains unclear whether serum WFA<jats:sup>+<\/jats:sup>\u2010M2BP levels are associated with the progression of liver histology in primary sclerosing cholangitis (PSC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010eight children and adolescents with pediatric\u2010onset PSC (male\u00a0:\u00a0female patient ratio,\u00a020:8; median age at diagnosis, 9\u00a0years) were enrolled in this study. The relation between serum WFA<jats:sup>+<\/jats:sup>\u2010M2BP levels and clinical characteristics was retrospectively evaluated. Moreover, receiver operating characteristic (ROC) analysis was used to determine whether serum WFA<jats:sup>+<\/jats:sup>\u2010M2BP levels could be a reliable marker to identify PSC patients with advanced liver histology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>According to the Ludwig classification of liver histological stage, 28 patients were classified into the four stages. The WFA<jats:sup>+<\/jats:sup>\u2010M2BP level, aspartate aminotransferase (AST) to platelet ratio index (APRI), and hyaluronic acid correlated significantly with liver histological stage. Moreover, WFA<jats:sup>+<\/jats:sup>\u2010M2BP showed a significant positive correlation (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) with autoimmune hepatitis overlap, AST, alanine aminotransferase (ALT), \u03b3\u2010glutamyltransferase, total bilirubin, immunoglobulin G, APRI, and hyaluronic acid. A ROC analysis was undertaken to distinguish the patients with advanced stage disease (stage 3\u20134) from those with early stage disease (stage 0\u20132). It showed that WFA<jats:sup>+<\/jats:sup>\u2010M2BP yielded the highest area under the ROC curve value (0.898) among four surrogate makers (APRI, 0.850; Fibrosis\u20104 index, 0.806; and AST\/ALT ratio, 0.802). Moreover, WFA<jats:sup>+<\/jats:sup>\u2010M2BP yielded the highest sensitivity, specificity, positive predictive value, and negative predictive value among the four markers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Serum WFA<jats:sup>+<\/jats:sup>\u2010M2BP levels are useful to identify patients with advanced liver histology in pediatric PSC.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.13004","type":"journal-article","created":{"date-parts":[[2017,11,23]],"date-time":"2017-11-23T04:06:52Z","timestamp":1511410012000},"page":"355-363","source":"Crossref","is-referenced-by-count":18,"title":["Usefulness of serum <scp><i>Wisteria floribunda<\/i><\/scp> agglutinin\u2010positive Mac\u20102 binding protein in children with primary sclerosing cholangitis"],"prefix":"10.1111","volume":"48","author":[{"given":"Shuichiro","family":"Umetsu","sequence":"first","affiliation":[{"name":"Department of Pediatric Hepatology and Gastroenterology Saiseikai Yokohamashi Tobu Hospital  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayano","family":"Inui","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hepatology and Gastroenterology Saiseikai Yokohamashi Tobu Hospital  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsuyoshi","family":"Sogo","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hepatology and Gastroenterology Saiseikai Yokohamashi Tobu Hospital  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruki","family":"Komatsu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Toho University Medical Center Sakura Hospital  Sakura Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoo","family":"Fujisawa","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hepatology and Gastroenterology Saiseikai Yokohamashi Tobu Hospital  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,12,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23294"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.06.052"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2003.50289"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10024-005-0020-0"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2008.10.019"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.22320"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050640615616012"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000001368"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01103.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i42.12141"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v9.i8.409"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep01065"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27305"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2015.118"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-014-1007-2"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-016-1235-8"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.12596"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.12712"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(99)80297-9"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2003.50346"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21178"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00432479"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1047"},{"key":"e_1_2_7_25_1","article-title":"Clinical implication of serum Wisteria floribunda agglutinin\u2010positive Mac\u20102\u2010binding protein in treatment naive chronic hepatitis B","author":"Nishikawa H","year":"2016","journal-title":"Hepatol Res"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.12575"}],"container-title":["Hepatology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhepr.13004","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hepr.13004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T10:50:41Z","timestamp":1695552641000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hepr.13004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,20]]},"references-count":25,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["10.1111\/hepr.13004"],"URL":"https:\/\/doi.org\/10.1111\/hepr.13004","archive":["Portico"],"relation":{},"ISSN":["1386-6346","1872-034X"],"issn-type":[{"value":"1386-6346","type":"print"},{"value":"1872-034X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,20]]}}}