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In the era of DAAs, surveillance of hepatocellular carcinoma (HCC) after eradication of HCV by anti\u2010HCV therapy is particularly important. As is well known, an advanced state of hepatic fibrosis is the major risk factor for developing HCC. Therefore, an increased understanding of various factors associated with disease progression and development of HCC in CHC patients is essential for implementing personalized treatment and surveillance of disease progression and HCC. Recent genome\u2010wide association studies (GWAS) have identified several host genetic variants influencing treatment efficacy or clinical course in HCV infection. 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