{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T19:37:07Z","timestamp":1770752227260,"version":"3.50.0"},"reference-count":20,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,6,4]],"date-time":"2018-06-04T00:00:00Z","timestamp":1528070400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:p>Immunoglobulin (Ig)G4\u2010related autoimmune hepatitis (AIH) is a recently proposed subtype that responds well to steroid treatment; however, its pathogenesis remains unclear. We report here a 65\u2010year\u2010old Japanese woman with skin itching and lip swelling. She had liver injury with jaundice, which persisted despite stopping anti\u2010allergic agents. Blood chemistry revealed highly elevated serum IgG and IgG4 (535\u00a0mg\/dL) levels, and positive anti\u2010nuclear antibody. The diagnosis of AIH was based on liver biopsy. Notably, the IgG4<jats:sup>+<\/jats:sup>\/IgG<jats:sup>+<\/jats:sup> cell ratio was 85%. On fluorodeoxyglucose (FDG) positron emission tomography\/computed tomography, robust signal intensity was found in the liver, and in enlarged lymph nodes and salivary glands with confirmed IgG4<jats:sup>+<\/jats:sup> cell infiltration. Immunofluorescence analysis of the liver biopsy specimen indicated clear expression of glucose transporter\u20103 (Glut\u20103) in IgG4<jats:sup>+<\/jats:sup> inflammatory cells infiltrating into the portal area. This is the first report of simultaneous strong accumulation of FDG and Glut\u20103 expression in IgG4\u2010related AIH, which might aid in elucidating the pathogenesis of this disease.<\/jats:p>","DOI":"10.1111\/hepr.13188","type":"journal-article","created":{"date-parts":[[2018,5,8]],"date-time":"2018-05-08T00:15:23Z","timestamp":1525738523000},"page":"937-944","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Marked accumulation of fluorodeoxyglucose and inflammatory cells expressing glucose transporter\u20103 in immunoglobulin G4\u2010related autoimmune hepatitis"],"prefix":"10.1111","volume":"48","author":[{"given":"Toshihiro","family":"Araki","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine Kurume University School of Medicine  Kurume 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