{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T04:00:50Z","timestamp":1792555250851,"version":"4.5.0"},"reference-count":33,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,6,7]],"date-time":"2018-06-07T00:00:00Z","timestamp":1528329600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Spleen stiffness is increased in liver cirrhosis (LC). We attempted to characterize the pathological features of spleen in LC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We compared pathological findings of resected spleen tissues of 28 LC patients and those of six healthy controls. In addition, we measured spleen stiffness before splenectomy by shear wave elastography in nine LC patients. After splenectomy, we examined the relationship between spleen stiffness and pathological findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Passive congestion of the spleen was more frequently observed in LC patients than in controls (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). The sinus was wider in LC patients than in controls (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). In the spleens of the LC patients, diffuse \u03b1\u2010smooth muscle actin (\u03b1SMA) expression of sinusoidal mesenchymal cells and deposition of collagen fibers on the perisinusoidal wall were observed. In nine LC patients whose spleen stiffness was examined, the width of the sinus increased along with spleen stiffness (<jats:italic>r<\/jats:italic>\u2009=\u20090.89, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). Spleen stiffness was higher in the spleen tissues with diffuse \u03b1SMA expression of sinusoidal mesenchymal cells than in those with partial \u03b1SMA expression of sinusoidal mesenchymal cells (<jats:italic>P<\/jats:italic>\u2009=\u20090.01). The degree of fibrosis was higher in the LC patients with diffuse \u03b1SMA expression of the red pulp than in those with partial \u03b1SMA expression of the red pulp (<jats:italic>P<\/jats:italic>\u2009=\u20090.03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In the LC patients, spleen tissues showed passive congestion with a dilated sinus, diffuse \u03b1SMA expression of sinusoidal mesenchymal cells, and deposition of collagen fibers on the perisinusoidal wall. This contributed to spleen stiffness.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.13195","type":"journal-article","created":{"date-parts":[[2018,5,16]],"date-time":"2018-05-16T00:54:33Z","timestamp":1526432073000},"page":"1000-1007","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Pathological findings that contribute to tissue stiffness in the spleen of liver cirrhosis patients"],"prefix":"10.1111","volume":"48","author":[{"given":"Reiichiro","family":"Kondo","sequence":"first","affiliation":[{"name":"Department of Pathology Kurume University School of Medicine  Kurume Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayoshi","family":"Kage","sequence":"additional","affiliation":[{"name":"Kurume University Research Center for Innovative Cancer Therapy  Kurume Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroko","family":"Iijima","sequence":"additional","affiliation":[{"name":"Ultrasound Imaging Center, Division of Hepatobiliary and Pancreatic Disease, Department of Internal Medicine Hyogo College of Medicine  Nishinomiya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiro","family":"Fujimoto","sequence":"additional","affiliation":[{"name":"Department of Surgery Hyogo College of Medicine  Nishinomiya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Nishimura","sequence":"additional","affiliation":[{"name":"Ultrasound Imaging Center, Division of Hepatobiliary and Pancreatic Disease, Department of Internal Medicine Hyogo College of Medicine  Nishinomiya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhiro","family":"Aizawa","sequence":"additional","affiliation":[{"name":"Ultrasound Imaging Center, Division of Hepatobiliary and Pancreatic Disease, Department of Internal Medicine Hyogo College of Medicine  Nishinomiya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Akiba","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Kurume University Hospital  Kurume Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5292-2785","authenticated-orcid":false,"given":"Yoshiki","family":"Naito","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Kurume University Hospital  Kurume Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hironori","family":"Kusano","sequence":"additional","affiliation":[{"name":"Department of Pathology Kurume University School of Medicine  Kurume Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masamichi","family":"Nakayama","sequence":"additional","affiliation":[{"name":"Department of Pathology Kurume University School of Medicine  Kurume Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaro","family":"Mihara","sequence":"additional","affiliation":[{"name":"Department of Pathology Kurume University School of Medicine  Kurume Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiko","family":"Tanigawa","sequence":"additional","affiliation":[{"name":"Department of Pathology Kurume University School of Medicine  Kurume Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirohisa","family":"Yano","sequence":"additional","affiliation":[{"name":"Department of Pathology Kurume University School of Medicine  Kurume Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,6,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI24282"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-012-0703-z"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2016.10.041"},{"key":"e_1_2_6_5_1","first-page":"303","article-title":"Performance of a new elastographic method (ARFI technology) compared to unidimensional transient elastography in the noninvasive assessment of chronic hepatitis C. 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