{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:46:32Z","timestamp":1773017192052,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2018,8,6]],"date-time":"2018-08-06T00:00:00Z","timestamp":1533513600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Hepatic fibrosis is the most important factor for estimating the prognosis of patients with non\u2010alcoholic fatty liver disease (NAFLD). A novel non\u2010invasive scoring system, the FM\u2010fibro index, showed high accuracy in a pilot study. The purpose of this study was to validate the efficacy of the FM\u2010fibro index in a multicenter cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Among 18 institutions, we analyzed 400 Japanese patients with biopsy\u2010proven NAFLD. We evaluated the accuracies of the FM\u2010fibro index, CA\u2010fibro index, and European Liver Fibrosis (ELF) panel by area under the receiver operator characteristics curves (AUROC). The FM\u2010fibro index includes three formulas for type IV collagen 7S, hyaluronic acid, and vascular cell adhesion molecule\u20101.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 400 patients, 205 were women, and the median age was 56\u00a0years. The histological distribution of Matteoni types 1, 2, 3, and 4 was 11, 40, 15, and 334, and the distribution of hepatic fibrosis stages 0 to 4 was 67, 183, 55, 63, and 32, respectively. The AUROCs of the FM\u2010fibro index, CA\u2010fibro index, and ELF panel for non\u2010alcoholic steatohepatitis (NASH)\u2010related fibrosis were 0.7178\/0.7095\/0.7065, 0.7093, and 0.7245, respectively. The sensitivity and specificity of the FM\u2010fibro index for predicting NASH\u2010related fibrosis was 0.5359\/0.5210\/0.4641 and 0.8333\/0.8182\/0.8788, respectively. The accuracy of the FM\u2010fibro index was not significantly different from that of the CA\u2010fibro index or the ELF panel.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The FM\u2010fibro index can predict NASH\u2010related fibrosis with sufficient accuracy compared with previous scoring systems. Further analyses that verify the accuracy of the FM\u2010fibro index to distinguish significant or advanced fibrosis in patients with NAFLD are awaited. (UMIN\u2010CTR: UMIN000018158).<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.13226","type":"journal-article","created":{"date-parts":[[2018,7,5]],"date-time":"2018-07-05T03:37:50Z","timestamp":1530761870000},"page":"1099-1107","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Accuracy of non\u2010invasive scoring systems for diagnosing non\u2010alcoholic steatohepatitis\u2010related fibrosis: Multicenter validation study"],"prefix":"10.1111","volume":"48","author":[{"given":"Yoshito","family":"Itoh","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Kyoto Prefectural University of Medicine  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuya","family":"Seko","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Kyoto Prefectural University of Medicine  Kyoto 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