{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T09:36:25Z","timestamp":1771580185756,"version":"3.50.1"},"reference-count":9,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2018,8,9]],"date-time":"2018-08-09T00:00:00Z","timestamp":1533772800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP17fk0210108h0001"],"award-info":[{"award-number":["JP17fk0210108h0001"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Sustained suppression of hepatitis B surface antigen (HBsAg) production after interferon (IFN) treatment has not been reported for children with genotype C chronic hepatitis B virus (HBV) infection, which is prevalent in Asia. Among children with hepatitis B envelope antigen\u2010positive genotype C chronic HBV infection, we compared the efficacy of combination therapy with nucleotide analogues and IFN\u2010\u03b1 in 11 children with 12 historical cases treated with IFN monotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The combination of lamivudine and conventional IFN\u2010\u03b1 was introduced for the first three patients; the other eight patients were treated with entecavir and pegylated IFN.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Demographic factors as well as baseline HBsAg titers and HBV\u2010DNA levels were similar between the two groups. In the combination therapy group, viral loads were suppressed in 9\/11 to below 4.0\u00a0log\u00a0copies\/mL both at the end of the therapy (EOT) and at 6\u00a0months after EOT. In contrast, in the IFN monotherapy group, suppression of viral loads was observed in 2\/12 and 3\/12 at EOT and at 6\u00a0months after EOT, respectively. In the combination therapy group, HBsAg titers dropped from 4.03 at pretreatment to 2.91\u00a0log\u00a0IU\/mL at 6\u00a0months after EOT with 4\/11 showing a drop to below 1000\u00a0IU\/mL (one patient achieved HBsAg clearance). In contrast, the amount of HBsAg did not change during the corresponding periods in the IFN monotherapy group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our preliminary results suggest that combination therapy might be effective in the suppression of HBsAg production as well as HBV\u2010DNA production for children with genotype C chronic HBV infection.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.13227","type":"journal-article","created":{"date-parts":[[2018,7,7]],"date-time":"2018-07-07T13:58:20Z","timestamp":1530971900000},"page":"1172-1177","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Suppression of hepatitis B surface antigen production by combination therapy with nucleotide analogues and interferon in children with genotype C hepatitis B virus infection"],"prefix":"10.1111","volume":"48","author":[{"given":"Hitoshi","family":"Tajiri","sequence":"first","affiliation":[{"name":"Department of Pediatrics Osaka General Medical Center  Osaka"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoko","family":"Takano","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Osaka General Medical Center  Osaka"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhito","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Virology and Liver Unit Nagoya City University Graduate School of Medical Sciences  Nagoya"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Murakami","sequence":"additional","affiliation":[{"name":"Division of Pediatrics and Perinatology Tottori University  Yonago Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Brooks","sequence":"additional","affiliation":[{"name":"Department of Microbiology\/Immunology State University of New York at Buffalo  Buffalo New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,8,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23934"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2014.962075"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.09.043"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-017-1315-4"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840190629"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2005.09.020"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.3851\/IMP2319"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.12007"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2014.06.059"}],"container-title":["Hepatology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhepr.13227","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hepr.13227","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T04:21:46Z","timestamp":1694751706000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hepr.13227"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,9]]},"references-count":9,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["10.1111\/hepr.13227"],"URL":"https:\/\/doi.org\/10.1111\/hepr.13227","archive":["Portico"],"relation":{},"ISSN":["1386-6346","1872-034X"],"issn-type":[{"value":"1386-6346","type":"print"},{"value":"1872-034X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,9]]},"assertion":[{"value":"2018-01-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}