{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:32:23Z","timestamp":1791199943467,"version":"4.2.0"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,8,31]],"date-time":"2018-08-31T00:00:00Z","timestamp":1535673600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006453","name":"Taisho Toyama Pharmaceutical Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>No pharmacological therapies are approved for non\u2010alcoholic fatty liver disease (NAFLD). Luseogliflozin, a sodium glucose cotransporter 2 inhibitor, has been developed for the treatment of adults with type 2 diabetes (T2DM). The aim of this prospective, single\u2010arm study is to evaluate the efficacy of luseogliflozin on hepatic fat content and glycated hemoglobin (HbA1c) in T2DM patients with NAFLD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty T2DM patients with NAFLD were treated with luseogliflozin 2.5\u00a0mg\/day for 24\u00a0weeks. Primary end\u2010points were changes in HbA1c and hepatic steatosis evaluated by magnetic resonance imaging\u2013hepatic fat fraction from baseline. Secondary end\u2010points were changes in metabolic and hepatic function\u2010related parameters, including hepatic fibrosis markers (Fibrosis\u20104 index, NAFLD fibrosis score, type IV collagen 7S. and <jats:styled-content style=\"fixed-case\"><jats:italic>Wisteria floribunda<\/jats:italic><\/jats:styled-content> agglutinin\u2010positive Mac\u20102 binding protein).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Not only HbA1c and transaminase activities but also hepatic fat content were significantly decreased after 24\u00a0weeks of therapy with luseogliflozin. The reduction of hepatic fat content was significantly correlated with the reduction of alanine aminotransferase. Although hepatic fibrosis markers were unchanged, serum ferritin levels reduced and serum albumin significantly increased after the treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Luseogliflozin can be a novel promising agent for the treatment of T2DM patients with NAFLD. Prospective randomized controlled trials are warranted to confirm this impact of luseogliflozin onT2DM with NAFLD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.13236","type":"journal-article","created":{"date-parts":[[2018,7,27]],"date-time":"2018-07-27T07:19:08Z","timestamp":1532675948000},"page":"64-71","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":96,"title":["Effect of luseogliflozin on hepatic fat content in type 2 diabetes patients with non\u2010alcoholic fatty liver disease: A prospective, single\u2010arm trial (LEAD trial)"],"prefix":"10.1111","volume":"49","author":[{"given":"Yoshio","family":"Sumida","sequence":"first","affiliation":[{"name":"Division of Hepatology and Pancreatology, Department of Internal Medicine Aichi Medical University  Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenta","family":"Murotani","sequence":"additional","affiliation":[{"name":"Biostatistics Center, Graduate School of Medicine Kurume University  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miyoko","family":"Saito","sequence":"additional","affiliation":[{"name":"Nakakinen Clinic Medical Corporation Kenseikai  Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsuko","family":"Tamasawa","sequence":"additional","affiliation":[{"name":"Nakakinen Clinic Medical Corporation Kenseikai  Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Osonoi","sequence":"additional","affiliation":[{"name":"Nakakinen Clinic Medical Corporation Kenseikai  Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Yoneda","sequence":"additional","affiliation":[{"name":"Division of Hepatology and Pancreatology, Department of Internal Medicine Aichi Medical University  Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Osonoi","sequence":"additional","affiliation":[{"name":"Nakakinen Clinic Medical Corporation Kenseikai  Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,8,31]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28431"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.27126"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2011.04724.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-013-0911-1"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.12840"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1504720"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1611925"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabet.2015.10.003"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.12834"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-017-1364-8"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.curtheres.2017.07.002"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep4.1019"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.12856"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13061"},{"key":"e_1_2_6_16_1","unstructured":"Ethical Guidelines for Medical and Health Research Involving Human Subjects. 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