{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T13:28:41Z","timestamp":1758634121588},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,12,5]],"date-time":"2018-12-05T00:00:00Z","timestamp":1543968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>It is reportedly difficult to accurately assess the liver reserve capacity of patients with HIV\/hepatitis C virus (HCV) co\u2010infection through contaminated blood products by the Child\u2013Pugh (CP) classification. Therefore, we investigated a clinically applicable scoring system in determining the risk of esophageal varices in HIV\/HCV co\u2010infected patients, known as latent portal hypertension leading to esophageal varices.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010three patients with HIV\/HCV co\u2010infection underwent clinical examinations, including endoscopy and assessment of hepatic reserve, in our department between 2009 and 2017. Child\u2013Pugh score, the recently developed albumin\u2013bilirubin (ALBI) grade, and the albumin\u2013indocyanine green evaluation (ALICE) were compared to evaluate their diagnostic accuracy for the detection of esophageal varices using the area under the receiver operating characteristic curve (AUROC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The patients were all male hemophiliacs and were positive for both HIV and HCV antibodies, with a median age of 45\u00a0years (range, 29\u201366\u00a0years). Thirty\u2010seven patients (84.1%) were classified as CP A at the examination. The comparison of AUROCs showed a superior diagnostic accuracy for ALICE (AUROC\u2009=\u20090.814) to detect esophageal varices. The positive prediction rate was the highest with ALICE if \u22122.325 was set, and the negative prediction rate was the highest with ALBI if \u22122.575 was set. The ALICE showed the highest accuracy compared to other two scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The ALICE score was found to be the most valuable system for portal hypertension in HIV\/HCV co\u2010infected hemophilia patients. Because of its high specificity, ALICE for secondary surveillance could be used after other markers such as the aspartate aminotransferase to platelet ratio index and Fibrosis\u20104 index.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.13279","type":"journal-article","created":{"date-parts":[[2018,10,25]],"date-time":"2018-10-25T11:24:28Z","timestamp":1540466668000},"page":"147-152","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Relationship between various hepatic function scores and the formation of esophageal varices in patients with HIV\/hepatitis C virus co\u2010infection due to contaminated blood products for hemophilia"],"prefix":"10.1111","volume":"49","author":[{"given":"Tomoko","family":"Yoshimoto","sequence":"first","affiliation":[{"name":"Department of Surgery Nagasaki University Graduate School of Biomedical Sciences  Nagasaki 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