{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T16:34:48Z","timestamp":1784219688080,"version":"3.55.0"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,1,2]],"date-time":"2019-01-02T00:00:00Z","timestamp":1546387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this study was to evaluate the efficacy and safety of community\u2010based ombitasvir\/paritaprevir\/ritonavir plus ribavirin therapy for non\u2010cirrhotic patients with hepatitis C virus (HCV) genotype 2a infection in a real\u2010world setting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with HCV genotype 2a infection were enrolled in this study and received the therapy for 16\u00a0weeks at 11 specialized centers in Japan between October 2016 and July 2017. Among the 98 patients participating in the study, four patients were excluded because of the presence of cirrhosis and\/or genotype 2b infection. The remaining 94 patients were subjected to the analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The patients consisted of 38 women and 56 men, with a median age of 63\u00a0years. The rate of sustained virologic response (SVR) was 97.9%. The SVR rates were similar between patients with and without ribavirin dose reduction (96.0% vs. 98.6%, respectively). Of the two patients in whom treatment failed, one patient completed the treatment but relapsed at 4\u00a0weeks post\u2010treatment, whereas the other did not show virologic response and therefore discontinued treatment at week 9. At baseline, both patients had non\u2010structural protein (NS)5A resistance\u2010associated substitution (RAS) L31M but no NS3 RAS. At the time of relapse, the patient had NS5A RAS F28S. At the premature treatment discontinuation, the non\u2010responder had NS3 RAS D168V and NS5A RAS T24S. Ribavirin\u2010induced anemia was the most frequent adverse event.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Community\u2010based, 16\u2010week, ombitasvir\/paritaprevir\/ritonavir plus ribavirin therapy was highly efficacious and safe in non\u2010cirrhotic patients with HCV genotype 2a infection in a real\u2010world setting.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.13292","type":"journal-article","created":{"date-parts":[[2018,11,28]],"date-time":"2018-11-28T18:37:21Z","timestamp":1543430241000},"page":"369-376","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Efficacy and safety of ombitasvir\/paritaprevir\/ritonavir and ribavirin for chronic hepatitis patients infected with genotype 2a in Japan"],"prefix":"10.1111","volume":"49","author":[{"given":"Masanori","family":"Atsukawa","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine Nippon Medical School  Tokyo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihito","family":"Tsubota","sequence":"additional","affiliation":[{"name":"Core Research Facilities for Basic Science, Research Center for Medical Sciences Jikei University School of Medicine  Tokyo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1652-6168","authenticated-orcid":false,"given":"Hidenori","family":"Toyoda","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Ogaki Municipal Hospital  Ogaki"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Takaguchi","sequence":"additional","affiliation":[{"name":"Department of Hepatology Kagawa Prefectural Central Hospital  Takamatsu"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Nakamuta","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology National Hospital Organization Kyushu Medical Center  Fukuoka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsunamasa","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine St. Marianna University School of Medicine  Kawasaki"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0976-6761","authenticated-orcid":false,"given":"Toshifumi","family":"Tada","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Ogaki Municipal Hospital  Ogaki"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akemi","family":"Tsutsui","sequence":"additional","affiliation":[{"name":"Department of Hepatology Kagawa Prefectural Central Hospital  Takamatsu"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine St. Marianna University School of Medicine  Kawasaki"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Abe","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Shinmatsudo Central General Hospital  Matsudo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keizo","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Shinmatsudo Central General Hospital  Matsudo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruki","family":"Uojima","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Internal Medicine Kitasato University School of Medicine  Sagamihara"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadashi","family":"Ikegami","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Gastroenterology Hepatology Tokyo Medical University  Ibaraki Medical Center Ibaraki"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Asano","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Gastroenterology and Hepatology Tokyo Metropolitan Bokutoh Hospital  Tokyo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chisa","family":"Kondo","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine Nippon Medical School  Tokyo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai","family":"Koeda","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Gastroenterology Nippon Medical School Chiba Hokusoh Hospital  Inzai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomomi","family":"Okubo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Gastroenterology Nippon Medical School Chiba Hokusoh 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