{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T02:37:07Z","timestamp":1790563027343,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,1,28]],"date-time":"2019-01-28T00:00:00Z","timestamp":1548633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873897"],"award-info":[{"award-number":["81873897"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81571675"],"award-info":[{"award-number":["81571675"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>To assess the diagnostic accuracy of liver and spleen stiffness measured by 2\u2010D shear\u2010wave elastography (SWE) in evaluation of clinically significant and severe portal hypertension (CSPH and SPH, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Clinical data of 155 hepatitis B\u2010related cirrhosis patients and their liver and spleen stiffness (L\u2010SWE and S\u2010SWE, respectively) were collected. The diagnostic performances of L\u2010SWE, S\u2010SWE, the liver stiffness\u2013spleen diameter to platelet ratio score (LSPS) and portal hypertension risk score were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred and four patients were eligible for analysis. Clinically significant and severe PH were detected in 84 and 74 patients, respectively. Liver and spleen stiffness were significantly correlated with hepatic venous pressure gradient in overall, CSPH, and SPH groups (<jats:italic>r<\/jats:italic><jats:sub><jats:italic>L<\/jats:italic><\/jats:sub>\u2009=\u20090.607, 0.554, and 0.412; <jats:italic>r<\/jats:italic><jats:sub><jats:italic>S<\/jats:italic><\/jats:sub>\u2009=\u20090.665, 0.566, and 0.467, respectively; all <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). The area under the receiver operating characteristic curves of L\u2010SWE, S\u2010SWE, LSPS, and PH risk score were 0.72 (95% confidence interval [CI], 0.49\u20130.95), 0.81 (95% CI, 0.55\u20130.97), 0.76 (95% CI, 0.51\u20130.96), and 0.73 (95% CI, 0.55\u20130.88) for CSPH, and 0.77 (95% CI, 0.51\u20130.93), 0.85 (95% CI, 0.59\u20130.96), 0.80 (95% CI, 0.58\u20130.98), and 0.80 (95% CI, 0.59\u20130.93) for SPH. The best cut\u2010off of L\u2010SWE for determining CSPH and SPH were 16.1\u00a0kPa (sensitivity, 78%; specificity, 72%) and 23.5\u00a0kPa (sensitivity, 81%; specificity, 79%). For S\u2010SWE, the best cut\u2010offs were 25.3\u00a0kPa (sensitivity, 85%; specificity, 79%) and 33.4\u00a0kPa (sensitivity, 74%; specificity, 70%). A cut\u2010off of L\u2010SWE\u2009&lt;13.2\u00a0kPa or S\u2010SWE\u2009&lt;23.2\u00a0kPa was able to rule out CSPH, whereas a cut\u2010off of L\u2010SWE\u2009&gt;24.9\u00a0kPa or S\u2010SWE\u2009&gt;34.2\u00a0kPa was able to rule in CSPH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Liver and spleen stiffness measured by 2\u2010D SWE are reliable and promising non\u2010invasive parameters to assess CSPH and SPH.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.13306","type":"journal-article","created":{"date-parts":[[2018,12,31]],"date-time":"2018-12-31T22:21:51Z","timestamp":1546294911000},"page":"540-549","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Portal hypertension in hepatitis B\u2010related cirrhosis: Diagnostic accuracy of liver and spleen stiffness by 2\u2010D shear\u2010wave elastography"],"prefix":"10.1111","volume":"49","author":[{"given":"Yu\u2010li","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Ultrasound, Zhongshan Hospital Fudan University  Shanghai China"},{"name":"Shanghai Institute of Medical Imaging Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9998-0904","authenticated-orcid":false,"given":"Hong","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Zhongshan Hospital Fudan University  Shanghai China"},{"name":"Shanghai Institute of Medical Imaging Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian\u2010tian","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Zhongshan Hospital Fudan University  Shanghai China"},{"name":"Shanghai Institute of Medical Imaging Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi\u2010yun","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Zhongshan Hospital Fudan University  Shanghai China"},{"name":"Shanghai Institute of Medical Imaging Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi\u2010yao","family":"Chen","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Medical Imaging Fudan University  Shanghai China"},{"name":"Department of Gastroenterology, Zhongshan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian\u2010jun","family":"Luo","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Medical Imaging Fudan University  Shanghai China"},{"name":"Department of Interventional Radiology, Zhongshan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010ping","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Zhongshan Hospital Fudan University  Shanghai China"},{"name":"Shanghai Institute of Medical Imaging Fudan University  Shanghai 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