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Histologically, CD8<jats:sup>+<\/jats:sup> T cells had infiltrated the biliary epithelium of the extrahepatic bile duct. We reached the diagnosis of secondary SC induced by pembrolizumab. Although we treated him with high\u2010dose corticosteroids, laboratory data showed only a moderate response. Clinicians should recognize that immune checkpoint inhibitors can sometimes cause severe and irreversible SC.<\/jats:p>","DOI":"10.1111\/hepr.13329","type":"journal-article","created":{"date-parts":[[2019,3,12]],"date-time":"2019-03-12T16:48:09Z","timestamp":1552409289000},"page":"950-956","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Secondary sclerosing cholangitis with hemobilia induced by pembrolizumab: Case report and review of published work"],"prefix":"10.1111","volume":"49","author":[{"given":"Yudai","family":"Koya","sequence":"first","affiliation":[{"name":"Third Department of Internal Medicine University of Occupational and Environmental Health  Kitakyushu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michihiko","family":"Shibata","sequence":"additional","affiliation":[{"name":"Third Department of Internal Medicine University of Occupational and Environmental Health  Kitakyushu 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