{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:11:40Z","timestamp":1791216700661,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,4,25]],"date-time":"2019-04-25T00:00:00Z","timestamp":1556150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008665","name":"Osaka Medical Research Foundation for Intractable Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Idiopathic portal hypertension (IPH), extrahepatic portal obstruction (EHO), and Budd\u2013Chiari syndrome (BCS) are characterized by aberrant portal hemodynamics of unknown etiology. The aim of this study was to explore trends in the descriptive epidemiology of these diseases through periodical nationwide surveys.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Nationwide epidemiologic surveys were undertaken in 1999, 2005, and 2015 using the same protocol. The survey targets were selected from all departments of gastrointestinal medicine, surgery, pediatrics, and pediatric surgery in Japan by stratified random sampling according to the number of beds. We asked each department to complete a mail\u2010back questionnaire on the annual numbers of patients with IPH, EHO, and BCS during the preceding year.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The estimated number of BCS patients increased from 280 (95% confidence interval, 200\u2013360) in 1999 survey to 410 (300\u2013530) in 2015 survey, whereas the number of IPH and EHO patients has remained largely unchanged during the 15\u00a0years (IPH was approximately 1000; EHO was approximately 770 in 2015 survey). The mean age at symptom onset was approximately 45\u00a0years for IPH, 30\u00a0years for EHO, and 40\u00a0years for BCS over the past 15\u00a0years. Those who described disease aggravation from the time of diagnosis accounted for approximately 10% of IPH, 15% of EHO, and 20% of BCS patients in each of the three surveys.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In Japan, the prevalence of BCS is increasing, while those of IPH and EHO appear to be stable. Clinical characteristics, including prognoses, have remained largely unchanged in the past 15\u00a0years.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.13343","type":"journal-article","created":{"date-parts":[[2019,4,4]],"date-time":"2019-04-04T00:09:41Z","timestamp":1554336581000},"page":"890-901","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Japanese periodical nationwide epidemiologic survey of aberrant portal hemodynamics"],"prefix":"10.1111","volume":"49","author":[{"given":"Satoko","family":"Ohfuji","sequence":"first","affiliation":[{"name":"Department of Public Health Osaka City University Graduate School of Medicine  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Furuichi","sequence":"additional","affiliation":[{"name":"The 4th Department of Internal Medicine Tokyo Medical University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiko","family":"Akahoshi","sequence":"additional","affiliation":[{"name":"Department of Disaster and Emergency Medicine Kyushu University Graduate School of Medical Sciences  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayoshi","family":"Kage","sequence":"additional","affiliation":[{"name":"Research Center for Innovative Cancer Therapy Kurume University  Kurume Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsutoshi","family":"Obara","sequence":"additional","affiliation":[{"name":"Department of Advanced Gastrointestinal Endoscopy Fukushima Medical University  Fukushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Hashizume","sequence":"additional","affiliation":[{"name":"Department of Disaster and Emergency Medicine Kyushu University Graduate School of Medical Sciences  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoka","family":"Matsuura","sequence":"additional","affiliation":[{"name":"Department of Public Health Osaka City University Graduate School of Medicine  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wakaba","family":"Fukushima","sequence":"additional","affiliation":[{"name":"Department of Public Health Osaka City University Graduate School of Medicine  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosikazu","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Public Health Jichi Medical University  Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,4,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v13.i13.1906"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1586\/17474124.2015.1024224"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2006.04492.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1872-034X.2012.01033.x"},{"key":"e_1_2_6_6_1","unstructured":"NakamuraY the Study Group on Epidemiologic Research for Intractable Diseases.A manual of a nationwide epidemiological survey for estimating the number of patients and assessing clinico\u2010epidemiological characteristics of patients with intractable diseases (3rd edition) [in Japanese].2017. 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