{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T05:43:20Z","timestamp":1791438200262,"version":"4.3.3"},"reference-count":37,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T00:00:00Z","timestamp":1559088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>We aimed to investigate the impact of interleukin (IL)\u201034 and YKL\u201040, regulators of hepatic fibrosis and tumor growth, on the prognosis of patients with non\u2010viral hepatocellular carcinoma (HCC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We enrolled 159 non\u2010viral HCC patients (age, 70.8\u2009\u00b1\u20098.5\u00a0years; female\/male, 43\/116). Of these, 86 patients were alive and 73 patients had died at the censor time point. Serum IL\u201034 and YKL\u201040 levels were quantified by enzyme\u2010linked immunosorbent assay. Patients were stratified by the median level of serum IL\u201034 to examine its effect on survival. Multivariate analysis and random forest analysis were used to evaluate the impact of IL\u201034 and YKL\u201040 on the prognosis of non\u2010viral HCC patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Interleukin\u201034 (hazard ratio [HR] 1.30; 95% confidence interval [CI], 1.13\u20131.49; <jats:italic>P<\/jats:italic>\u2009\u2264\u20090.01), tumor size (HR 1.63; 95% CI, 1.37\u20131.94; <jats:italic>P<\/jats:italic>\u2009\u2264\u20090.01), and tumor number (HR 1.53; 95% CI, 1.25\u20131.87; <jats:italic>P<\/jats:italic>\u2009\u2264\u20090.01) were independent predictive factors for survival. Furthermore, the survival rates were significantly lower in the high IL\u201034 group than in the low IL\u201034 group (5\u2010year survival rates, 34.7% vs. 59.8%, respectively; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). In the random forest analysis for survival, IL\u201034 was the third\u2010highest ranking factor, following tumor size and number. In a stratification analysis, serum \u03b1\u2010fetoprotein level and Fibrosis\u20104 index were independent positive risk factors for high serum IL\u201034 level. YKL\u201040 was not associated with prognosis in either the multivariate or random forest analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Interleukin\u201034 was an independent factor for survival of non\u2010viral HCC patients. Interleukin\u201034 might be associated with prognosis through tumor and hepatic fibrosis factors.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.13350","type":"journal-article","created":{"date-parts":[[2019,4,17]],"date-time":"2019-04-17T07:26:45Z","timestamp":1555486005000},"page":"1046-1053","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["High serum interleukin\u201034 level is a predictor of poor prognosis in patients with non\u2010viral hepatocellular carcinoma"],"prefix":"10.1111","volume":"49","author":[{"given":"Yu","family":"Noda","sequence":"first","affiliation":[{"name":"Division of Gastroenterology Kurume University School of Medicine  Kurume Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7064-4325","authenticated-orcid":false,"given":"Takumi","family":"Kawaguchi","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Kurume 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