{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T01:52:19Z","timestamp":1783648339659,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,7,11]],"date-time":"2019-07-11T00:00:00Z","timestamp":1562803200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>To elucidate the clinical factors having an impact on liver regeneration rate following preoperative portal vein embolization (PVE) and subsequent extended hepatectomy. The correlation between liver volume and functional recovery after extended hepatectomy was also investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Records of patients who underwent extended hepatectomy with extrahepatic bile duct resection following PVE for perihilar cholangiocarcinoma were reviewed retrospectively with attention to liver regeneration. All patients underwent computed tomography before PVE, after PVE (immediately before surgery), and on postoperative day (POD) 7. The kinetic growth rate (KGR) was calculated as the percent increase in liver volume relative to the future liver remnant volume per day after PVE (KGR<jats:sub>PVE<\/jats:sub>) and after POD 7 (KGR<jats:sub>POD7<\/jats:sub>) using the computed tomography images before PVE, after PVE, and on POD 7.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the 289 study patients, the median of KGR<jats:sub>PVE<\/jats:sub> was 1.35%\/day whereas that of KGR<jats:sub>POD7<\/jats:sub> was 5.56%\/day. The extent of liver resection had the greatest impact on both KGR<jats:sub>PVE<\/jats:sub> and KGR<jats:sub>POD7<\/jats:sub> and the impacts of other factors were less. There was a significant negative correlation between KGR<jats:sub>PVE<\/jats:sub> and KGR<jats:sub>POD7<\/jats:sub> (<jats:italic>P<\/jats:italic>\u2009=\u20090.002). No correlations were observed between KGR<jats:sub>PVE<\/jats:sub> or KGR<jats:sub>POD7<\/jats:sub> and serum total bilirubin and prothrombin time \u2013 international normalized ratio on POD 7, nor in the incidence of liver failure after surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Early phase liver regeneration after extended hepatectomy was largely influenced by the extent of liver resection and showed no correlation with the indices of liver failure. There was a discrepancy between volume and functional recovery in early phase liver regeneration.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.13378","type":"journal-article","created":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T23:21:09Z","timestamp":1558567269000},"page":"1227-1235","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Discrepancy between volume and functional recovery in early phase liver regeneration following extended hepatectomy with extrahepatic bile duct resection"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2238-0633","authenticated-orcid":false,"given":"Takashi","family":"Maeda","sequence":"first","affiliation":[{"name":"Division of Surgical Oncology, Department of Surgery Nagoya University Graduate School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukihiro","family":"Yokoyama","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology, Department of Surgery Nagoya University Graduate School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoki","family":"Ebata","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology, Department of Surgery Nagoya University Graduate School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Igami","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology, Department of Surgery Nagoya University Graduate School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Mizuno","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology, Department of Surgery Nagoya University Graduate School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junpei","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology, Department of Surgery Nagoya University Graduate School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunsuke","family":"Onoe","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology, Department of Surgery Nagoya University Graduate School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiko","family":"Ando","sequence":"additional","affiliation":[{"name":"Center for Advanced Medicine and Clinical Research Nagoya University Hospital  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Nagino","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology, Department of Surgery Nagoya University Graduate School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,7,11]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.12872"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.13077"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2522080922"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.8807"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-013-2278-0"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000079064.08263.8E"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1091-255X(02)00370-0"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181b674df"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2012.10.018"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-017-3467-1"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hpb.2016.07.005"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000201482.11876.14"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.7084"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-002-0304-z"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.5531"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2014.04.036"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2013.08.022"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2010.10.001"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-016-3744-2"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.9908"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.20182"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-017-3389-y"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2015.01.031"},{"key":"e_1_2_5_25_1","first-page":"1815","article-title":"Clinical evaluation of cefteram pivoxil in the pediatric field","volume":"42","author":"Meguro H","year":"1989","journal-title":"Jpn J Antibiot"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3182708b57"}],"container-title":["Hepatology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhepr.13378","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hepr.13378","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/hepr.13378","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hepr.13378","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T11:14:33Z","timestamp":1694171673000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hepr.13378"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,11]]},"references-count":25,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["10.1111\/hepr.13378"],"URL":"https:\/\/doi.org\/10.1111\/hepr.13378","archive":["Portico"],"relation":{},"ISSN":["1386-6346","1872-034X"],"issn-type":[{"value":"1386-6346","type":"print"},{"value":"1872-034X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,11]]},"assertion":[{"value":"2018-12-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}