{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,12]],"date-time":"2025-07-12T22:45:04Z","timestamp":1752360304159,"version":"3.40.5"},"reference-count":43,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,7,10]],"date-time":"2019-07-10T00:00:00Z","timestamp":1562716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP19fk0210053","JP19fk0310103","JP19fk0210021","JP19fk0310101","JP19fk0210022","JP19fk0210047","JP19fk0210048","JP19fk0210058","19fk0210018"],"award-info":[{"award-number":["JP19fk0210053","JP19fk0310103","JP19fk0210021","JP19fk0310101","JP19fk0210022","JP19fk0210047","JP19fk0210048","JP19fk0210058","19fk0210018"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP19K0940007"],"award-info":[{"award-number":["JP19K0940007"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Ultrasound technology can now be used for liver stiffness measurement (LSM) and for evaluating the amount of hepatic fat quantitatively known as the controlled attenuation parameter (CAP). This study aimed to determine the applicable cut\u2010off values of LSM and the CAP for primary hepatocellular carcinoma (HCC), and to investigate their clinical usefulness for assessing HCC risk in patients with chronic liver disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 1054 patients (88 with primary HCC and 966 without HCC) whose LSM and the CAP were measured by transient elastography with clinically evident hepatitis\u00a0C virus (419 patients), hepatitis\u00a0B virus (377 patients), and non\u2010alcoholic fatty liver disease (258 patients) were enrolled in this study. Subsequently, a total of 966 patients who did not have HCC initially were followed, and the usefulness of the cut\u2010off values of LSM and CAP for HCC development were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In hepatitis\u00a0C virus patients, the incidence of HCC development was significantly higher among those with a combination of LSM\u2009\u22658.0\u00a0kPa and CAP \u2264221\u00a0dB\/m than among those with other values (log\u2013rank test 0.0239, hazard ratio 2.66, 95%CI 1.07\u20136.47, <jats:italic>P<\/jats:italic>\u00a0=\u20090.0362). In non\u2010alcoholic fatty liver disease patients, the incidence of HCC development was significantly higher among those with a combination of LSM\u2009\u22655.4\u00a0kPa and CAP \u2264265\u00a0dB\/m than among others (log\u2013rank test 0.0040, hazard ratio 8.91, 95% CI 1.47\u201367.97, <jats:italic>P<\/jats:italic>\u00a0=\u20090.0192).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In the hepatitis\u00a0C virus and non\u2010alcoholic fatty liver disease groups, a combination of LSM and the CAP cut\u2010off values would be useful for screening to identify the high\u2010risk group for primary HCC development.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.13391","type":"journal-article","created":{"date-parts":[[2019,6,20]],"date-time":"2019-06-20T14:09:05Z","timestamp":1561039745000},"page":"1207-1217","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Assessing the risk of hepatocellular carcinoma by combining liver stiffness and the controlled attenuation parameter"],"prefix":"10.1111","volume":"49","author":[{"given":"Takaaki","family":"Izumi","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Hokkaido University Faculty of Medicine and Graduate School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuya","family":"Sho","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Hokkaido University Faculty of Medicine and Graduate School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3891-5113","authenticated-orcid":false,"given":"Kenichi","family":"Morikawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Hokkaido University Faculty of Medicine and Graduate School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taku","family":"Shigesawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Hokkaido University Faculty of Medicine and Graduate School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuharu","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Hokkaido University Faculty of Medicine and Graduate School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihisa","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Hokkaido University Faculty of Medicine and Graduate School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masatsugu","family":"Ohara","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Hokkaido University Faculty of Medicine and Graduate School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2953-6242","authenticated-orcid":false,"given":"Naoki","family":"Kawagishi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Hokkaido University Faculty of Medicine and Graduate School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Machiko","family":"Umemura","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Hokkaido University Faculty of Medicine and Graduate School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoe","family":"Shimazaki","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Hokkaido University Faculty of Medicine and Graduate School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megumi","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Hokkaido University Faculty of Medicine and Graduate School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masato","family":"Nakai","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Hokkaido University Faculty of Medicine and Graduate School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0098-9106","authenticated-orcid":false,"given":"Goki","family":"Suda","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Hokkaido University Faculty of Medicine and Graduate School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuteru","family":"Natsuizaka","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Hokkaido University Faculty of Medicine and Graduate School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Hokkaido University Faculty of Medicine and Graduate School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Kudo","sequence":"additional","affiliation":[{"name":"Division of Laboratory and Transfusion Medicine Hokkaido University Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mutsumi","family":"Nishida","sequence":"additional","affiliation":[{"name":"Division of Laboratory and Transfusion Medicine Hokkaido University Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kota","family":"Ono","sequence":"additional","affiliation":[{"name":"Clinical Research and Medical Innovation Center Hokkaido University Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaru","family":"Baba","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology JCHO Hokkaido Hospital  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Furuya","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology JCHO Hokkaido Hospital  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoya","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Hokkaido University Faculty of Medicine and Graduate School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,7,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26180"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.24663"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2012.10.025"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coviro.2016.09.010"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13142"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2012.10.001"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2003.07.001"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-017-9789-y"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24121"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22870"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13179"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2013.09.029"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2017.389"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.33160\/yam.2017.06.006"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000343875"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.310.6980.633"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(1950)3:1<32::AID-CNCR2820030106>3.0.CO;2-3"},{"key":"e_1_2_6_19_1","unstructured":"WHO.GLOBOCAN 2012: Estimated Cancer IncidenceMortality and Prevalence Worldwide in 2012;2012."},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/14728222.2017.1369959"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-10-4567-7_15"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21178"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21669"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510290424"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2006.02.008"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510270535"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-131-3-199908030-00003"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e31825079f1"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.11.012"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2008.03895.x"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27382"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-011-1659-1"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v22.i8.2494"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v9.i11.533"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-009-0112-0"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13031"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22734"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.216077"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23312"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.13231"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.11.048"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.10.026"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2016.09.150"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.13286"}],"container-title":["Hepatology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhepr.13391","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hepr.13391","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/hepr.13391","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/am-pdf\/10.1111%2Fhepr.13391","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hepr.13391","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T11:15:01Z","timestamp":1694171701000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hepr.13391"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,10]]},"references-count":43,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["10.1111\/hepr.13391"],"URL":"https:\/\/doi.org\/10.1111\/hepr.13391","archive":["Portico"],"relation":{},"ISSN":["1386-6346","1872-034X"],"issn-type":[{"type":"print","value":"1386-6346"},{"type":"electronic","value":"1872-034X"}],"subject":[],"published":{"date-parts":[[2019,7,10]]},"assertion":[{"value":"2019-04-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}