{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T06:08:43Z","timestamp":1773814123633,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T00:00:00Z","timestamp":1564012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>This study aimed to assess the clinical utility of preoperative evaluation of liver fibrosis using platelet\u2013albumin\u2013bilirubin (PALBI) grade, Fibrosis\u20104 index (FIB\u20104), and aspartate transaminase\u2010to\u2010platelet ratio index (APRI) for hepatocellular carcinoma (HCC) patients and explore the clinical impact of these models with regard to perioperative risks and HCC prognosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between January 2003 and December 2018, 305 consecutive patients who underwent hepatectomy for HCC were enrolled.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The APRI showed the most robust diagnostic performance through each fibrosis stage among three models (PALBI, FIB\u20104, and APRI): fibrosis stage 3 (f3), area under the curve [AUC]\u2009=\u20090.55, 0.72, and 0.76; and f4, AUC\u2009=\u20090.51, 0.71, and 0.76, respectively). In addition, survival analysis revealed that all three models were significantly associated with HCC prognosis. PALBI (grade 1 vs. 2, 3): recurrence\u2010free survival (RFS): median survival time (MST), 34 vs. 17\u00a0months, 0.007; overall survival (OS): MST, 115 vs. 68, 0.02. FIB\u20104 (grade 1, 2 vs. 3): RFS: MST, 34 vs. 22, 0.004, OS: MST, 120 vs. 63, 0.0001. APRI (grade 1, 2 vs. 3), RFS: MST, 30 vs. 20, 0.0005; OS: MST, 107 vs. 55, 0.0003. Among three scoring systems, only PALBI grade was significantly associated with both operative time (median, 303 vs. 340\u00a0min, 0.01) and intraoperative blood loss (median, 581 vs. 859\u00a0mL, 0.03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study showed robust performances of selected liver reserve and fibrosis models to predict HCC prognosis. Of them, PALBI might be used for assessing perioperative risks for hepatectomy for HCC.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.13400","type":"journal-article","created":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T18:28:36Z","timestamp":1562005716000},"page":"1305-1315","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Comparison of non\u2010invasive liver reserve and fibrosis models: Implications for surgery and prognosis for hepatocellular carcinoma"],"prefix":"10.1111","volume":"49","author":[{"given":"Fuminori","family":"Sonohara","sequence":"first","affiliation":[{"name":"Department of Gastroenterological Surgery Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suguru","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery Nagoya University Graduate School of Medicine  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