{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T22:05:27Z","timestamp":1769551527936,"version":"3.49.0"},"reference-count":32,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T00:00:00Z","timestamp":1565308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>We assessed the problems and efficacy of glecaprevir + pibrentasvir (GLE\/PIB) therapy for patients infected with hepatitis C virus (HCV) in the real world.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A total of 423 patients infected with HCV who started treatment at eight different centers in Japan were enrolled in the study. Glecaprevir (300\u00a0mg) and pibrentasvir (120\u00a0mg) were given once daily for 8\u00a0weeks to 246 non\u2010cirrhotic direct\u2010acting antiviral (DAA)\u2010naive patients with HCV genotype (GT)\u20101 or\u00a0\u20102, and for 12\u00a0weeks to patients who: were DAA\u2010naive cirrhotic (<jats:italic>n<\/jats:italic>\u2009=\u200955), had experienced DAA failure (<jats:italic>n<\/jats:italic>\u2009=\u200978), were cirrhotic and had DAA failure (<jats:italic>n<\/jats:italic>\u2009=\u200937), and were other GT\u20101\/2 (<jats:italic>n<\/jats:italic>\u2009=\u20097). Anti\u2010HCV efficacy was defined as a sustained virologic response 12\u00a0weeks post\u2010treatment (SVR12). The evaluation was undertaken in an intention\u2010to\u2010treat (ITT) population and in patients who were assessed at SVR12 (modified ITT population).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the ITT population, 220 (89%) patients on the 8\u2010week regimen and 164 (93%) patients on the 12\u2010week regimen achieved SVR12. The 30 dropout patients were predominantly men and with GT\u20102. All other DAA\u2010naive GT\u20101 patients achieved SVR12. The 12\u2010week regimen resulted in 100% SVR12 in 41 GT\u20102 patients. Nine patients did not achieve SVR12: two DAA naive with GT\u20102a, two GT\u20103b patients, two GT\u20101 patients with discontinuation, and three other GT\u20101 patients with a history of DAA failure. Four of seven patients who discontinued treatment due to severe adverse effects were\u00a0more than 75\u00a0years old.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Glecaprevir + pibrentasvir had a remarkable anti\u2010HCV effect in GT\u20101 and GT\u20102 patients, but not in GT\u20103b patients. Although this therapy was reasonably safe, it is necessary to carefully consider elderly and dropout patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.13410","type":"journal-article","created":{"date-parts":[[2019,7,19]],"date-time":"2019-07-19T19:53:56Z","timestamp":1563566036000},"page":"1365-1373","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Intention\u2010to\u2010treat assessment of glecaprevir + pibrentasvir combination therapy for patients with chronic hepatitis C in the real world"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9119-4864","authenticated-orcid":false,"given":"Akihiro","family":"Tamori","sequence":"first","affiliation":[{"name":"Department of Hepatology Osaka City University Graduate School of Medicine  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuaki","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Showa University  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatehiro","family":"Kagawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Tokai University  Isehara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Takaguchi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Kagawa Prefectural Central Hospital  Takamatsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"Nouso","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Okayama City General Medical Center  Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiaki","family":"Iwasaki","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Okayama University  Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahito","family":"Minami","sequence":"additional","affiliation":[{"name":"Aiseikai Yamashina Hospital  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hoang","family":"Hai","sequence":"additional","affiliation":[{"name":"Department of Hepatology Osaka City University Graduate School of Medicine  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaru","family":"Enomoto","sequence":"additional","affiliation":[{"name":"Department of Hepatology Osaka City University Graduate School of Medicine  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norifumi","family":"Kawada","sequence":"additional","affiliation":[{"name":"Department of Hepatology Osaka City University Graduate School of Medicine  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,8,9]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"WHO.Hepatitis C. 18 July 2018. 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