{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:26:07Z","timestamp":1760955967313,"version":"3.40.5"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,10,25]],"date-time":"2019-10-25T00:00:00Z","timestamp":1571961600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>The cause of thrombocytopenia in patients with chronic hepatitis\u00a0C virus (HCV) infection is multifactorial: hypersplenism, decreased thrombopoietin levels, and myelosuppression induced by HCV. Platelet counts increase after eradication of HCV; however, this mechanism is not fully understood. Therefore, the aim of this study was to determine the influence of these three factors on platelet counts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analyzed data from 109 HCV\u2010infected patients with platelet counts \u2264150\u2009\u00d7\u200910<jats:sup>3<\/jats:sup>\/\u03bcL who achieved viral eradication using interferon\u2010free anti\u2010HCV therapy. Changes in hematological parameters, thrombopoietin levels, HCV titers, and spleen volumes, and the correlations among them were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>HCV RNA levels significantly decreased at 4\u00a0weeks after initiating antiviral therapy. Platelet counts rapidly increased at 4\u00a0weeks from baseline (120\u2009\u00b1\u200935 vs. 106\u2009\u00b1\u200928\u2009\u00d7\u200910<jats:sup>3<\/jats:sup>\/\u03bcL, <jats:italic>P<\/jats:italic>\u00a0&lt;\u20090.001), and remained at a plateau until 48\u00a0weeks after initiating antiviral therapy. Neutrophil counts showed the same pattern. Spleen volume was evaluated in 32 patients and, among them, it decreased in 21 patients, but remained unchanged in seven and increased in four. In addition to patients with decreased spleen volume, patients with unchanged spleen volume showed marginally increased platelet counts. Thrombopoietin levels did not correlate with platelet counts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Platelet counts increased at 4\u00a0weeks after starting anti\u2010HCV treatment. Our results suggest that this rapid change was possibly caused by improvement of hypersplenism and HCV\u2010induced myelosuppression resulting from anti\u2010HCV therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.13426","type":"journal-article","created":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T06:21:36Z","timestamp":1568010096000},"page":"47-56","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Rapid increase of platelet counts during antiviral therapy in patients with hepatitis\u00a0C virus infection"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1255-5201","authenticated-orcid":false,"given":"Yoji","family":"Ishizu","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masatoshi","family":"Ishigami","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7919-6071","authenticated-orcid":false,"given":"Kazuhiko","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Meijo Hospital  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Honda","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2229-990X","authenticated-orcid":false,"given":"Teiji","family":"Kuzuya","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takanori","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuhiro","family":"Fujishiro","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,10,25]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_5_2_1","DOI":"10.1016\/j.cgh.2009.02.021"},{"doi-asserted-by":"publisher","key":"e_1_2_5_3_1","DOI":"10.1016\/j.jhep.2009.11.017"},{"doi-asserted-by":"publisher","key":"e_1_2_5_4_1","DOI":"10.1007\/s00535-010-0233-5"},{"doi-asserted-by":"publisher","key":"e_1_2_5_5_1","DOI":"10.1111\/j.1365-2036.2007.03512.x"},{"doi-asserted-by":"publisher","key":"e_1_2_5_6_1","DOI":"10.1111\/liv.13317"},{"doi-asserted-by":"publisher","key":"e_1_2_5_7_1","DOI":"10.1111\/jgh.13252"},{"doi-asserted-by":"publisher","key":"e_1_2_5_8_1","DOI":"10.1016\/j.jhep.2016.05.027"},{"doi-asserted-by":"publisher","key":"e_1_2_5_9_1","DOI":"10.1002\/hep.21941"},{"doi-asserted-by":"publisher","key":"e_1_2_5_10_1","DOI":"10.1007\/s10620-012-2162-z"},{"doi-asserted-by":"publisher","key":"e_1_2_5_11_1","DOI":"10.1001\/jama.266.6.849"},{"doi-asserted-by":"publisher","key":"e_1_2_5_12_1","DOI":"10.1038\/bmt.2012.244"},{"doi-asserted-by":"publisher","key":"e_1_2_5_13_1","DOI":"10.1053\/j.gastro.2017.07.016"},{"doi-asserted-by":"publisher","key":"e_1_2_5_14_1","DOI":"10.1111\/apt.13315"},{"doi-asserted-by":"publisher","key":"e_1_2_5_15_1","DOI":"10.1053\/j.gastro.2012.05.035"},{"doi-asserted-by":"publisher","key":"e_1_2_5_16_1","DOI":"10.1002\/hep.28610"},{"doi-asserted-by":"publisher","key":"e_1_2_5_17_1","DOI":"10.1046\/j.1365-2141.2001.02824.x"},{"doi-asserted-by":"publisher","key":"e_1_2_5_18_1","DOI":"10.1111\/liv.12908"},{"key":"e_1_2_5_19_1","first-page":"2580","article-title":"Measurement of spleen size and its relation to hypersplenism and portal hemodynamics in portal hypertension due to hepatic cirrhosis","volume":"91","author":"Shah SH","year":"1996","journal-title":"Am J Gastroenterol"},{"issue":"4","key":"e_1_2_5_20_1","first-page":"381","article-title":"Thrombocytopenia in chronic hepatitis C","volume":"19","author":"Olariu M","year":"2010","journal-title":"J Gastrointestin Liver Dis"},{"doi-asserted-by":"publisher","key":"e_1_2_5_21_1","DOI":"10.1046\/j.1365-2141.2000.02132.x"},{"doi-asserted-by":"publisher","key":"e_1_2_5_22_1","DOI":"10.1007\/s00705-012-1321-z"},{"doi-asserted-by":"publisher","key":"e_1_2_5_23_1","DOI":"10.1097\/MEG.0000000000000667"},{"doi-asserted-by":"publisher","key":"e_1_2_5_24_1","DOI":"10.1097\/MEG.0000000000001013"},{"doi-asserted-by":"publisher","key":"e_1_2_5_25_1","DOI":"10.1136\/gut.44.5.754"},{"doi-asserted-by":"publisher","key":"e_1_2_5_26_1","DOI":"10.1097\/00042737-200107000-00006"},{"doi-asserted-by":"publisher","key":"e_1_2_5_27_1","DOI":"10.1002\/hep.510230607"},{"doi-asserted-by":"publisher","key":"e_1_2_5_28_1","DOI":"10.1002\/hep.21669"},{"doi-asserted-by":"publisher","key":"e_1_2_5_29_1","DOI":"10.1053\/jhep.2003.50346"},{"doi-asserted-by":"publisher","key":"e_1_2_5_30_1","DOI":"10.3748\/wjg.v22.i4.1711"},{"doi-asserted-by":"publisher","key":"e_1_2_5_31_1","DOI":"10.1111\/jgh.13758"},{"doi-asserted-by":"publisher","key":"e_1_2_5_32_1","DOI":"10.1111\/liv.13256"},{"doi-asserted-by":"publisher","key":"e_1_2_5_33_1","DOI":"10.1111\/eci.13056"},{"doi-asserted-by":"publisher","key":"e_1_2_5_34_1","DOI":"10.7326\/0003-4819-132-7-200004040-00002"},{"doi-asserted-by":"publisher","key":"e_1_2_5_35_1","DOI":"10.1111\/j.0902-4441.2006.t01-1-EJH2888.x"},{"doi-asserted-by":"publisher","key":"e_1_2_5_36_1","DOI":"10.1155\/2014\/532191"}],"container-title":["Hepatology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hepr.13426","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/hepr.13426","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hepr.13426","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T16:32:11Z","timestamp":1693326731000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hepr.13426"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,25]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1111\/hepr.13426"],"URL":"https:\/\/doi.org\/10.1111\/hepr.13426","archive":["Portico"],"relation":{},"ISSN":["1386-6346","1872-034X"],"issn-type":[{"type":"print","value":"1386-6346"},{"type":"electronic","value":"1872-034X"}],"subject":[],"published":{"date-parts":[[2019,10,25]]},"assertion":[{"value":"2019-07-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}