{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:11:45Z","timestamp":1747185105023,"version":"3.40.5"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,1,5]],"date-time":"2020-01-05T00:00:00Z","timestamp":1578182400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Chronic liver insufficiency is often associated with alteration in amino acid metabolism. We evaluated the prognostic value of changes in serum amino acid concentrations in patients with primary biliary cholangitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 75 primary biliary cholangitis patients who started urusodeoxycholic acid therapy were retrospectively enrolled. Baseline serum concentrations of branched\u2010chain amino acids and tyrosine, and branched\u2010chain amino acid\u2010to\u2010tyrosine ratio were determined. The hazard ratios of factors associated with liver\u2010related events were analyzed by Cox proportional hazard analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 75 patients enrolled, 12 showed a decrease in serum branched\u2010chain amino acid levels, and 15 showed an increase in serum tyrosine levels. The branched\u2010chain amino acid\u2010to\u2010tyrosine ratio decreased in 16 patients. During a median 5.6\u2010year follow up, liver\u2010related events occurred in 11 patients. Multivariate analysis showed that high serum tyrosine levels at baseline and high alkaline phosphatase levels 48\u00a0weeks after starting urusodeoxycholic acid therapy were independent risk factors for event occurrence. From the receiver operator characteristics curve analysis, serum tyrosine concentration &gt;110\u00a0\u03bcmol\/L was identified as a cut\u2010off value with an adjusted hazard ratio of 20.9 (95% confidence interval 4.3\u2013101.5, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Kaplan\u2013Meier analysis showed that the 5\u2010year cumulative incidences of event occurrence in patients with high and low serum tyrosine concentration were 56.5% and 5.5%, respectively (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). The 10\u2010year survival probabilities also showed significant differences between patients with high and low serum tyrosine concentration (44.9% vs. 92.0%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Elevation of serum tyrosine concentration indicates a high risk of liver\u2010related events in primary biliary cholangitis patients receiving urusodeoxycholic acid therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.13434","type":"journal-article","created":{"date-parts":[[2019,10,25]],"date-time":"2019-10-25T19:43:15Z","timestamp":1572032595000},"page":"214-223","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Prognostic significance of serum tyrosine concentration in patients with primary biliary cholangitis under ursodeoxycholic acid therapy"],"prefix":"10.1111","volume":"50","author":[{"given":"Nozomi","family":"Amano","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Juntendo University Shizuoka Hospital  Shizuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Juntendo University Shizuoka Hospital  Shizuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sho","family":"Hayashida","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Juntendo University Shizuoka Hospital  Shizuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sho","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Juntendo University Shizuoka Hospital  Shizuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sho","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Juntendo University Shizuoka Hospital  Shizuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayato","family":"Murata","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Juntendo University Shizuoka Hospital  Shizuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hironori","family":"Tsuzura","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Juntendo University Shizuoka Hospital  Shizuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunsuke","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Juntendo University Shizuoka Hospital  Shizuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Shimada","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Juntendo University Shizuoka Hospital  Shizuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuyori","family":"Iijima","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Juntendo University Shizuoka Hospital  Shizuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryo","family":"Wada","sequence":"additional","affiliation":[{"name":"Department of Pathology Juntendo University Shizuoka Hospital  Shizuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihito","family":"Nagahara","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Juntendo University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0006-8948","authenticated-orcid":false,"given":"Takuya","family":"Genda","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Juntendo University Shizuoka Hospital  Shizuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,1,5]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30145"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199405123301903"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2000.20240"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-013-0782-5"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lts.2003.09.018"},{"key":"e_1_2_5_7_1","unstructured":"OPTN\/SPTR 2010 Annual Data Report. 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