{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T16:34:51Z","timestamp":1784219691971,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,11,19]],"date-time":"2019-11-19T00:00:00Z","timestamp":1574121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Hepatitis\u00a0C virus genotype\u00a02 is common in East Asia, sub\u2010Saharan Africa, and Latin America. However, many countries in these areas lag behind other areas of the world in government approval for new direct\u2010acting antivirals. The aim of this study was to evaluate the treatment outcome of ledipasvir\/sofosbuvir (LDV\/SOF) for patients with chronic hepatitis\u00a0C virus genotype\u00a02 infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a two\u2010part multicenter, real\u2010world cohort study. Study\u00a01 consisted of 58 consecutive patients who were treated with LDV\/SOF for 12\u00a0weeks. Study\u00a02 used propensity score matching for LDV\/SOF (<jats:italic>n<\/jats:italic>\u2009=\u200958) and glecaprevir\/pibrentasvir (<jats:italic>n<\/jats:italic>\u2009=\u2009207) treatment groups (1:1) with a set of clinically important variables. Sustained viral response 12\u00a0weeks after the end of treatment (SVR12) and adverse events were evaluated in both studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In study\u00a01, the overall SVR12 rates of the intention\u2010to\u2010treat and modified intention\u2010to\u2010treat populations were 94.8% (55\/58) and 96.5% (55\/57), respectively. High SVR12 rates were observed in almost all subgroups, including older age, compensated cirrhosis, and treatment experience. In study\u00a02, propensity score matching of the entire study population yielded 52 matched pairs with similar baseline characteristics. There were no statistically significant differences between the LDV\/SOF (96.1%) and glecaprevir\/pibrentasvir (98.0%) groups in the overall SVR12 rates of the modified intention\u2010to\u2010treat populations, and their rates of treatment discontinuation and adverse events were similar.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Treatment with LDV\/SOF for hepatitis\u00a0C virus genotype\u00a02 resulted in a high rate of SVR12 and excellent tolerability. The outcomes of LDV\/SOF were very similar to those of glecaprevir\/pibrentasvir.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.13437","type":"journal-article","created":{"date-parts":[[2019,10,21]],"date-time":"2019-10-21T16:00:30Z","timestamp":1571673630000},"page":"174-181","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Ledipasvir and sofosbuvir for 12\u00a0weeks for hepatitis\u00a0C virus genotype\u00a02 infection: A propensity score matched analysis"],"prefix":"10.1111","volume":"50","author":[{"given":"Eiichi","family":"Ogawa","sequence":"first","affiliation":[{"name":"Department of General Internal Medicine Kyushu University Hospital  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideyuki","family":"Nomura","sequence":"additional","affiliation":[{"name":"The Center for Liver Disease Shin\u2010Kokura Hospital  Kitakyushu Japan"},{"name":"Department of Medicine Haradoi Hospital  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Nakamuta","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Kyushu Medical Center National Hospital Organization  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Kawano","sequence":"additional","affiliation":[{"name":"Department of Medicine Kitakyushu Municipal Medical Center  Kitakyushu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazufumi","family":"Dohmen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Chihaya Hospital  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiji","family":"Kajiwara","sequence":"additional","affiliation":[{"name":"Kajiwara Clinic  Kitakyushu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeaki","family":"Satoh","sequence":"additional","affiliation":[{"name":"Center for Liver Disease Kokura Medical Center  Kitakyushu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshimasa","family":"Koyanagi","sequence":"additional","affiliation":[{"name":"Department of Medicine Fukuoka City Hospital  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Medicine Hamanomachi Hospital  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aritsune","family":"Ooho","sequence":"additional","affiliation":[{"name":"Department of Hepatology Steel Memorial Yawata Hospital  Kitakyushu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Azuma","sequence":"additional","affiliation":[{"name":"Department of Medicine Kyushu Central Hospital  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norihiro","family":"Furusyo","sequence":"additional","affiliation":[{"name":"Department of General Internal Medicine Kyushu University Hospital  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Shimoda","sequence":"additional","affiliation":[{"name":"Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Kyushu General Internal Medicine Center Haradoi Hospital  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"The Kyushu University Liver Disease Study (KULDS) Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,11,19]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200107053450107"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26141"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.7326\/M16-2575"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.05.049"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14507"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.07.027"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy585"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.03.026"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1316145"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.12312"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2016.10.012"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.13246"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.13311"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.01.017"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.11.011"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13685"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1306218"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13069"},{"key":"e_1_2_6_20_1","unstructured":"US Food and Drug Administration Center for Drug Evaluation and Research. Virology review sofosbuvir and ledipasvir. Available at:https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/nda\/2014\/205834Orig1s000MicroR.pdf. Accessed April 22 2019."},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2009.04.002"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-137-8-200210150-00015"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.03.014"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.14615"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-018-4979-6"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14799"}],"container-title":["Hepatology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhepr.13437","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hepr.13437","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/hepr.13437","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hepr.13437","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T01:50:55Z","timestamp":1694137855000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hepr.13437"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,19]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["10.1111\/hepr.13437"],"URL":"https:\/\/doi.org\/10.1111\/hepr.13437","archive":["Portico"],"relation":{},"ISSN":["1386-6346","1872-034X"],"issn-type":[{"value":"1386-6346","type":"print"},{"value":"1872-034X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,19]]},"assertion":[{"value":"2019-07-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}