{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T18:18:14Z","timestamp":1780683494844,"version":"3.54.1"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,12,29]],"date-time":"2019-12-29T00:00:00Z","timestamp":1577577600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Recently, a new method has been developed to diagnose hepatic steatosis with attenuation coefficients based on the ultrasound\u2010guided attenuation parameter (UGAP). We investigated whether fibrosis identified by hepatic stiffness measurements based on magnetic resonance elastography (MRE) affects attenuation coefficient measurement using UGAP for the evaluation of hepatic steatosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 608 patients with chronic liver disease were analyzed. Correlations between magnetic resonance imaging\u2010determined proton density fat fraction (PDFF) or MRE value and attenuation coefficients were evaluated. In addition, the interaction between hepatic fibrosis and the attenuation coefficient was analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The correlation coefficient (<jats:italic>r<\/jats:italic>) between PDFF values and attenuation coefficient values was 0.724, indicating a strong relationship. Conversely, the <jats:italic>r<\/jats:italic> between MRE values and attenuation coefficient values was \u22120.187, indicating almost no relationship. In the multiple regression assessment of the effect of PDFF and MRE on the attenuation coefficient based on UGAP, the <jats:italic>P<\/jats:italic>\u2010values for PDFF, MRE, and PDFF\u2009\u00d7\u2009MRE were\u2009&lt;\u20090.001, 0.277, and 0.903, respectively. In patients with non\u2010alcoholic fatty liver disease (<jats:italic>n<\/jats:italic>\u00a0=\u2009169), the <jats:italic>r<\/jats:italic> between PDFF values and attenuation coefficient values was 0.695, indicating a moderate relationship. Conversely, the <jats:italic>r<\/jats:italic> between MRE values and attenuation coefficient values was \u22120.068, indicating almost no relationship. In the multiple regression assessment of the effect of PDFF and MRE on the attenuation coefficient based on UGAP, the <jats:italic>P<\/jats:italic>\u2010values for PDFF, MRE, and PDFF\u2009\u00d7\u2009MRE were\u2009&lt;0.001, 0.948, and 0.706, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>UGAP\u2010determined attenuation coefficient was weakly affected by liver stiffness, an indicator of hepatic fibrosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.13442","type":"journal-article","created":{"date-parts":[[2019,10,29]],"date-time":"2019-10-29T22:53:06Z","timestamp":1572389586000},"page":"190-198","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Liver stiffness does not affect ultrasound\u2010guided attenuation coefficient measurement in the evaluation of hepatic 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Gastroenterology and Hepatology, Ogaki Municipal Hospital, Ogaki  Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Sone","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology, Ogaki Municipal Hospital, Ogaki  Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichi","family":"Hashinokuchi","sequence":"additional","affiliation":[{"name":"Department of Imaging Diagnosis, Ogaki Municipal Hospital, Ogaki  Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadanobu","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Department of Imaging Diagnosis, Ogaki Municipal Hospital, Ogaki  Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuma","family":"Oguri","sequence":"additional","affiliation":[{"name":"Ultrasound General Imaging, GE Healthcare, Hino  Tokyo 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