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In particular, in non\u2010alcoholic fatty liver disease and alcohol\u2010related liver disease, the two most common causes of chronic liver disease, a dysbiotic gut microbiota can influence intestinal permeability, allowing some pathogens or bacteria\u2010derived factors from the gut reaching the liver through the enterohepatic circulation contributing to liver injury, steatohepatitis, and fibrosis progression. Pathways involved are multiple, including changes in bile acid metabolism, intestinal ethanol production, generation of short\u2010chain fatty acids, and other by\u2010products. Bile acids act through dedicated bile acid receptors, farnesoid X receptor and TGR5, in both the ileum and the liver, influencing lipid metabolism, inflammation, and fibrogenesis. Currently, both non\u2010alcoholic fatty liver disease and alcohol\u2010related liver disease lack effective therapies, and therapeutic targeting of gut microbiota and bile acids enterohepatic circulation holds promise. In this review, we summarize current knowledge about the role of gut microbiota in the pathogenesis of non\u2010alcoholic fatty liver disease and alcohol\u2010related liver disease, as well as the relevance of microbiota or bile acid\u2010based approaches in the management of those liver diseases.<\/jats:p>","DOI":"10.1111\/hepr.13473","type":"journal-article","created":{"date-parts":[[2019,12,15]],"date-time":"2019-12-15T22:32:00Z","timestamp":1576449120000},"page":"407-418","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":66,"title":["Gut microbiota in non\u2010alcoholic fatty liver disease and alcohol\u2010related liver disease: Current concepts and perspectives"],"prefix":"10.1111","volume":"50","author":[{"given":"Juan P.","family":"Arab","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Mayo Clinic  Rochester Minnesota USA"},{"name":"Departamento de Gastroenterolog\u00eda, Escuela de Medicina Pontificia Universidad Cat\u00f3lica de Chile (Department of Gastroenterology, School of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile)  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Arrese","sequence":"additional","affiliation":[{"name":"Departamento de Gastroenterolog\u00eda, Escuela de Medicina Pontificia Universidad Cat\u00f3lica de Chile (Department of Gastroenterology, School of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile)  Santiago Chile"},{"name":"Centro de Envejecimiento y Regeneraci\u00f3n (CARE), Departamento de Biolog\u00eda Celular y Molecular, Facultad de Ciencias Biol\u00f3gicas Pontificia Universidad Cat\u00f3lica de Chile (Center of Aging and Regeneration UC (CARE UC), Cell and Molecular Biology Department, Pontificia Universidad Catolica de Chile, Santiago, Chile)  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay 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