{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:51:28Z","timestamp":1787014288924,"version":"build-2736575974"},"reference-count":48,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,1,22]],"date-time":"2020-01-22T00:00:00Z","timestamp":1579651200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To elucidate associations among liver disease, lipid profile, body mass index (BMI), ketonuria, and meal skipping under the influence of alcohol dehydrogenase\u20101B (ADH1B; rs1229984) and aldehyde dehydrogenase\u20102 (ALDH2; rs671) genotypes in men with alcohol dependence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We investigated the associations among these variables in 1768 Japanese men with alcohol dependence. Serum lipid levels were followed up after abstinence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The slow\u2010metabolizing\n                      <jats:italic>ADH1B<\/jats:italic>\n                      Arg\/Arg genotype and inactive\n                      <jats:italic>ALDH2<\/jats:italic>\n                      Glu\/Lys genotype increased the age\u2010 and drinking\u2010adjusted odds ratio or regression coefficient for fatty liver, ketonuria, and serum high\u2010density\u2010lipoprotein cholesterol levels (HDL\u2010C), and decreased these for cirrhosis and serum triglyceride levels (TG). The\n                      <jats:italic>ADH1B<\/jats:italic>\n                      Arg\/Arg genotype increased the adjusted regression coefficient for BMI and non\u2010HDL\u2010C. In addition to the positive interlinkage among fatty liver, BMI, and atherogenic dyslipidemia, positive associations were observed of fatty liver with ketonuria and meal skipping, of cirrhosis with the BMI, and of ketonuria with non\u2010HDL\u2010C. Negative associations were observed of cirrhosis with fatty liver, TG, non\u2010HDL\u2010C, and HDL\u2010C, and of ketonuria with BMI and TG. Overall, after admission for 4 or 6\u00a0weeks, the TG and HDL\u2010C decreased, and the serum low\u2010density lipoprotein cholesterol levels increased. However, there was no change of the serum low\u2010density lipoprotein in the patients with cirrhosis or of the serum TG in those with fatty liver.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These associations and the alterations in lipid profile after abstinence serve as useful information for a better understanding of the clinical features of men with alcohol dependence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hepr.13475","type":"journal-article","created":{"date-parts":[[2019,12,17]],"date-time":"2019-12-17T02:41:31Z","timestamp":1576550491000},"page":"565-577","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Associations among liver disease, serum lipid profile, body mass index, ketonuria, meal skipping, and the alcohol dehydrogenase\u20101B and aldehyde dehydrogenase\u20102 genotypes in Japanese men with alcohol dependence"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1869-1359","authenticated-orcid":false,"given":"Akira","family":"Yokoyama","sequence":"first","affiliation":[{"name":"National Hospital Organization Kurihama Medical and Addiction Center  Yokosuka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhito","family":"Taniki","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine Keio University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhiro","family":"Nakamoto","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine Keio University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kengo","family":"Tomita","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine National Defense Medical College  Tokorozawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachiko","family":"Hara","sequence":"additional","affiliation":[{"name":"National Hospital Organization Kurihama Medical and Addiction Center  Yokosuka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Mizukami","sequence":"additional","affiliation":[{"name":"National Hospital Organization Kurihama Medical and Addiction Center  Yokosuka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuya","family":"Maruyama","sequence":"additional","affiliation":[{"name":"National Hospital Organization Kurihama Medical and Addiction Center  Yokosuka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuji","family":"Yokoyama","sequence":"additional","affiliation":[{"name":"Department of Health Promotion National Institute of Public Health  Wako Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,1,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00197271"},{"key":"e_1_2_6_3_1","first-page":"707","article-title":"Involvement of genetic polymorphism of alcohol and aldehyde dehydrogenase in individual variation of alcohol metabolism","volume":"29","author":"Mizoi Y","year":"1994","journal-title":"Alcohol Alcohol"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ALC.0000108667.79219.4D"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/FPC.0b013e3282609e67"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2010.01202.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.13073"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.152.8.1219"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1086\/302540"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddm357"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-017-1402-6"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.12108"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.12069"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/agu048"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0133460"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/22.3.433"},{"key":"e_1_2_6_17_1","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"American Psychiatric Association","year":"1994"},{"key":"e_1_2_6_18_1","volume-title":"International Statistical Classification of Diseases and Related Health Problems. 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