{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T14:03:28Z","timestamp":1792677808125,"version":"4.5.0"},"reference-count":47,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,6,10]],"date-time":"2020-06-10T00:00:00Z","timestamp":1591747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Although some relationships between gut microbiota and liver diseases have been reported, it remains uncertain whether changes in gut microbiota owing to differences in race, food and living environment have similar effects. Response to ursodeoxycholic acid (UDCA) may predict the long\u2010term prognosis of patients with primary biliary cholangitis (PBC); however, little is known about the significance of the gut microbiome in patients with PBC. We elucidated the relationships among clinical profiles, biochemical response to UDCA and gut microbiome composition in patients with PBC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fecal samples from 76 patients with PBC treated at our hospital were collected; patients whose UDCA intake period was &lt;1\u00a0year were excluded. The microbiome structures of patients were determined using 16S ribosomal RNA gene sequencing and were statistically compared with those of healthy subjects. The structures of patients in the UDCA responder (<jats:italic>n<\/jats:italic>\u2009=\u200943) and non\u2010responder (<jats:italic>n<\/jats:italic>\u2009=\u200930) groups were compared according to the Nara criteria (reduction rate of gamma\u2010glutamyl transpeptidase, \u226569%, after 1\u00a0year).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with healthy subjects, bacterial diversity was lower in patients with PBC, with a decreased abundance of the order Clostridiales and increased abundance of Lactobacillales. The UDCA non\u2010responder group had a significantly lower population of the genus <jats:italic>Faecalibacterium<\/jats:italic>, known as butyrate\u2010producing beneficial bacteria (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05), although no significant differences in gender, body mass index, medicated drugs or other serological data were indicated between these two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Gut dysbiosis with loss of beneficial Clostridiales commensals was observed in patients with PBC. Decrease in <jats:italic>Faecalibacterium<\/jats:italic> abundance might predict the long\u2010term prognosis of patients with PBC.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.13509","type":"journal-article","created":{"date-parts":[[2020,4,29]],"date-time":"2020-04-29T00:15:06Z","timestamp":1588119306000},"page":"840-852","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":81,"title":["Gut dysbiosis associated with clinical prognosis of patients with primary biliary cholangitis"],"prefix":"10.1111","volume":"50","author":[{"given":"Masanori","family":"Furukawa","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Nara Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kei","family":"Moriya","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Nara Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiro","family":"Nakayama","sequence":"additional","affiliation":[{"name":"Laboratory of Microbial Technology, Division of Systems Bioengineering, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School Kyushu University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takako","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Medicine Nagoya City University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rie","family":"Momoda","sequence":"additional","affiliation":[{"name":"Laboratory of Microbial Technology, Division of Systems Bioengineering, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School Kyushu University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideto","family":"Kawaratani","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Nara Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3158-5318","authenticated-orcid":false,"given":"Tadashi","family":"Namisaki","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Nara Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinya","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Nara Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akitoshi","family":"Douhara","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Nara Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kosuke","family":"Kaji","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Nara Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuteru","family":"Kitade","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Nara Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naotaka","family":"Shimozato","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Nara Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiko","family":"Sawada","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Nara Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soichiro","family":"Saikawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Nara Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Takaya","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Nara Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koh","family":"Kitagawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Nara Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takemi","family":"Akahane","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Nara Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Mitoro","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Nara Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junichi","family":"Yamao","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Nara Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhito","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Medicine Nagoya City University Hospital"},{"name":"Department of Virology and Liver Unit Nagoya City University Graduate School of Medical Sciences  Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Yoshiji","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Nara Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-309990"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13568"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-018-0011-z"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v7.i3.425"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000447252"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19103003"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00154-3"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.02.019"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1383726"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510290301"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.12.029"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.07.038"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22428"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.01.003"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.02.031"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.12746"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/1462-2920.13401"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-313332"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy205"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2604"},{"key":"e_1_2_8_22_1","article-title":"SINTAX, a simple non\u2010Bayesian taxonomy classifier for 16S and ITS sequences","author":"Edgar RC","year":"2016","journal-title":"Biorxiv"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780471729259.mc01e05s27"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2011-12-6-r60"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24423"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2013.01.003"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21843"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-food-030212-182554"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0803978"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0025637"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12721"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1198469"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0804812105"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(00)70142-9"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08821"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4983"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-310376"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13568"},{"key":"e_1_2_8_39_1","first-page":"1","article-title":"Additional fibrate treatment in UDCA\u2010refractory PBC patients","volume":"00","author":"Chung SW","year":"2019","journal-title":"Liver Int"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/ismej.2016.176"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000000590"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.12073"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2013.828773"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12866-015-0400-1"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7007-11-61"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00248-010-9801-8"},{"key":"e_1_2_8_47_1","first-page":"2229","article-title":"Markers of activated inflammatory cells are associated with disease severity and intestinal microbiota in adults with non\u2010alcoholic fatty liver disease","volume":"42","author":"Schwenger KJP","year":"2018","journal-title":"Int J Mol Med"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.1965"}],"container-title":["Hepatology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhepr.13509","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hepr.13509","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/hepr.13509","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hepr.13509","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T06:29:46Z","timestamp":1693981786000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hepr.13509"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,10]]},"references-count":47,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["10.1111\/hepr.13509"],"URL":"https:\/\/doi.org\/10.1111\/hepr.13509","archive":["Portico"],"relation":{},"ISSN":["1386-6346","1872-034X"],"issn-type":[{"value":"1386-6346","type":"print"},{"value":"1872-034X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,10]]},"assertion":[{"value":"2019-09-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}