{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:51:36Z","timestamp":1787014296438,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,6,23]],"date-time":"2020-06-23T00:00:00Z","timestamp":1592870400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP18hk0102049h0001"],"award-info":[{"award-number":["JP18hk0102049h0001"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Repeat resection for intrahepatic recurrent hepatocellular carcinoma (HCC) is effective for the long\u2010term survival of patients; however, little is known about the surgical outcomes of extrahepatic nodules. The aim of this study is to investigate whether resection can contribute to the survival of patients with extrahepatic recurrent HCC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Under the conditions that intrahepatic recurrent HCC was absent or controlled by locoregional therapies, patients who had resectable extrahepatic recurrent HCC in the lymph nodes, adrenal gland, peritoneum, lung, or brain were included in this study. The survival of patients who did (Surgical group) and did not (Non\u2010surgical group, underwent other therapies) undergo resection for extrahepatic recurrent HCC was compared.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirty\u2010eight and 26 patients were included in the Surgical and Non\u2010surgical groups, respectively. No patient had severe postoperative complications. After a median follow\u2010up of 1.2 (range, 0.2\u20138.8) years, the median cumulative incidence of extrahepatic recurrent HCC was 1.2\u00a0years (95% confidence interval [CI], 0.4\u20133.5) in the Surgical group. The median overall survival was 5.3 (95% CI, 2.5\u20138.8) and 1.1 (0.8\u20132.3) years in the Surgical and Non\u2010surgical groups, respectively (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u20090.001). The 5\u2010year rates of survival were 60.5% and 9.1% in the Surgical and Non\u2010surgical groups, respectively. Surgical resection, \u03b1\u2010fetoprotein, disease\u2010free interval, and metastasis at the adrenal gland were the independent factors for overall survival.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Due to the favorable surgical outcomes, resection should be considered as one of the therapeutic choices for patients with extrahepatic recurrent HCC if intrahepatic recurrent HCC can be controlled by locoregional therapies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hepr.13526","type":"journal-article","created":{"date-parts":[[2020,6,23]],"date-time":"2020-06-23T10:49:04Z","timestamp":1592909344000},"page":"978-984","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Favorable outcomes of surgical resection for extrahepatic recurrent hepatocellular 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