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This study aimed to characterize clinical and histological features for distinguishing between AP\u2010AIH and DILI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Clinical, biochemical, and histological characteristics of AP\u2010AIH and DILI in clinically well\u2010characterized cases were compared in a standardized manner to clarify differences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In clinical evaluations, immunoglobulin G level and rate of anti\u2010nuclear antibody positivity were greater in AP\u2010AIH than DILI cases. As for diagnosis of each condition, significant (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01) differences were found for 10 features: lobular necrosis\/inflammation, cobblestone appearance of hepatocytes, plasma cell infiltration in liver parenchyma, centrilobular fibrosis, hepatic rosette formation in areas with cobblestone appearance, portal inflammation, interface hepatitis, prominent plasma cells in portal areas, bile duct injury, and hepatic rosette formation in periportal areas. The area under the curve and cut\u2010off values for the combination of these 10 features were 0.95 and 9 (sensitivity 86%, specificity 90%), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Combinations of histological features were found to be helpful for differentiating AP\u2010AIH from DILI, but we were not able to statistically identify an individual feature as definitive.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.13532","type":"journal-article","created":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T14:30:03Z","timestamp":1591713003000},"page":"1047-1061","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Histopathological analysis of autoimmune hepatitis with \u201cacute\u201d presentation: Differentiation from drug\u2010induced liver 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