{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T05:14:40Z","timestamp":1768972480513,"version":"3.49.0"},"reference-count":24,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,8,29]],"date-time":"2020-08-29T00:00:00Z","timestamp":1598659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2019M660840"],"award-info":[{"award-number":["2019M660840"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012151","name":"Sanming Project of Medicine in Shenzhen","doi-asserted-by":"publisher","award":["SZSM201612014"],"award-info":[{"award-number":["SZSM201612014"]}],"id":[{"id":"10.13039\/501100012151","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No.81803299"],"award-info":[{"award-number":["No.81803299"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>With the current coronavirus disease (COVID\u201019) pandemic and high endemic levels of chronic hepatitis B virus (HBV) infection worldwide, it is urgent to investigate liver function changes of COVID\u201019 patients with chronic HBV infection, and how severe acute respiratory syndrome coronavirus 2\u00a0(SARS\u2010CoV\u20102) infection in turn affects the course of chronic HBV infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We undertook a retrospective study based on 347 COVID\u201019 patients (21 vs. 326 with vs. without chronic HBV infection). With the propensity score matching (PSM) method, we yielded 20 and 51 matched patients for the HBV group and the non\u2010HBV group, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At the end of follow\u2010up, all of these 71 patients achieved SARS\u2010CoV\u20102 clearance (<jats:italic>P<\/jats:italic>\u2009=\u20090.1). During the follow\u2010up, 30% versus 31.4% in the HBV group versus non\u2010HBV group progressed to severe COVID\u201019 (<jats:italic>P<\/jats:italic>\u2009=\u20090.97). After PSM, the longitudinal changes of median values for liver biochemistries were not significantly different between the two groups. In the HBV group versus non\u2010HBV group, 35% (7\/20) versus 37.25% (19\/51) (<jats:italic>P<\/jats:italic>\u2009=\u20090.86) had abnormal alanine aminotransferase at least once during hospitalization, 30% (6\/20) versus 31.37% (16\/51) had abnormal aspartate aminotransferase (<jats:italic>P<\/jats:italic>\u2009=\u20090.91), 40% (8\/20) versus 37.25% (19\/51) had abnormal \u03b3\u2010glutamyltransferase (<jats:italic>P<\/jats:italic>\u2009=\u20090.83), and 45% (9\/20) versus 39.22% (20\/51) had abnormal total bilirubin levels (<jats:italic>P<\/jats:italic>\u2009=\u20090.91). Moreover, three patients in the HBV group had hepatitis B reactivation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Liver dysfunction presented in COVID\u201019 patients with\/without chronic HBV. Moreover, those COVID\u201019 patients co\u2010infected with chronic HBV could have a risk of hepatitis B reactivation. It is necessary to monitor liver function of COVID\u201019 patients, as well as HBV\u2010DNA levels for those co\u2010infected with HBV during the whole disease course.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.13553","type":"journal-article","created":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T23:44:28Z","timestamp":1596757468000},"page":"1211-1221","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":74,"title":["Longitudinal changes of liver function and hepatitis B reactivation in COVID\u201019 patients with pre\u2010existing chronic hepatitis B virus infection"],"prefix":"10.1111","volume":"50","author":[{"given":"Jiaye","family":"Liu","sequence":"first","affiliation":[{"name":"National Clinical Research Center for Infectious Diseases The Third People's Hospital of Shenzhen, The Second Affiliated Hospital of Southern University of Science and Technology  Shenzhen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingyan","family":"Wang","sequence":"additional","affiliation":[{"name":"Nuffield Department of Medicine, Medawar Building for Pathogen Research University of Oxford  Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingxian","family":"Cai","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Infectious Diseases The Third People's Hospital of Shenzhen, The Second Affiliated Hospital of Southern University of Science and Technology  Shenzhen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liqin","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deliang","family":"Huang","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Infectious Diseases The Third People's Hospital of Shenzhen, The Second Affiliated Hospital of Southern University of Science and Technology  Shenzhen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangde","family":"Zhou","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Infectious Diseases The Third People's Hospital of Shenzhen, The Second Affiliated Hospital of Southern University of Science and Technology  Shenzhen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"He","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Infectious Diseases The Third People's Hospital of Shenzhen, The Second Affiliated Hospital of Southern University of Science and Technology  Shenzhen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fu\u2010Sheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Treatment and Research Center for Infectious Diseases The Fifth Medical Center of PLA General Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Liu","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Infectious Diseases The Third People's Hospital of Shenzhen, The Second Affiliated Hospital of Southern University of Science and Technology  Shenzhen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Chen","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Infectious Diseases The Third People's Hospital of Shenzhen, The Second Affiliated Hospital of Southern University of Science and Technology  Shenzhen China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,8,29]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"World Health Organization.Novel Coronavirus (2019\u2010nCoV) situation reports. 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