{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T16:34:49Z","timestamp":1784219689940,"version":"3.55.0"},"reference-count":37,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,9,7]],"date-time":"2020-09-07T00:00:00Z","timestamp":1599436800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["19fk0210020h0003"],"award-info":[{"award-number":["19fk0210020h0003"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>We analyzed the impact of hepatitis C virus eradication by direct\u2010acting antiviral (DAA) therapy on the risk of development of hepatocellular carcinoma (HCC), prognosis, and portal hypertension in patients with liver cirrhosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The rate of HCC development and overall survival after achievement of sustained virological response (SVR) in 173 DAA\u2010treated compensated cirrhosis patients without HCC history were retrospectively compared with that of 125 cirrhosis patients who achieved SVR by interferon (IFN)\u2010based therapy or that of 85 cirrhosis patients who failed to respond to anti\u2010HCV therapy. Changes in esophagogastric varices (EGV) and incidence of portosystemic encephalopathy were analyzed in 87 consecutive cirrhosis patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The cumulative HCC development rates at 1, 3, and 5\u00a0years were 2%, 7%, and 7% for the DAA\u2010SVR group, significantly lower than the 3%, 7%, and 18% for the non\u2010SVR group (log\u2013rank, <jats:italic>P<\/jats:italic>\u00a0&lt;\u20090.001). The cumulative overall survival rates were also significantly improved in the DAA\u2010SVR group compared to the non\u2010SVR group (log\u2013rank, <jats:italic>P<\/jats:italic>\u00a0&lt;\u20090.001). These rates were similar between DAA\u2010SVR and IFN\u2010SVR groups (<jats:italic>P<\/jats:italic>\u00a0=\u20090.121 and 0.261, respectively). Esophagogastric varices were aggravated, and portosystemic encephalopathy occurred in a subset of cirrhosis patients who achieved SVR by DAA therapy. These events were more frequent in patients with large feeding vessels for EGV and portosystemic shunts at the time of SVR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Achievement of SVR by DAA therapy reduces the risk of HCC development and prolongs survival, similar to theresults achieved with IFN\u2010based therapy, but portal hypertension is not immediately improved in compensated liver cirrhosis patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.13554","type":"journal-article","created":{"date-parts":[[2020,8,7]],"date-time":"2020-08-07T06:15:00Z","timestamp":1596780900000},"page":"1222-1233","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Impact of viral eradication by direct\u2010acting antivirals on the risk of hepatocellular carcinoma development, prognosis, and portal hypertension in hepatitis C virus\u2010related compensated cirrhosis patients"],"prefix":"10.1111","volume":"50","author":[{"given":"Yuko","family":"Nagaoki","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Metabolism, Graduate School of Biomedical and Health Science Hiroshima University  Hiroshima Japan"},{"name":"Research Center for Hepatology and Gastroenterology Hiroshima University  Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michio","family":"Imamura","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Metabolism, Graduate School of Biomedical and Health Science Hiroshima University  Hiroshima Japan"},{"name":"Research Center for Hepatology and Gastroenterology Hiroshima University  Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Teraoka","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Metabolism, Graduate School of Biomedical and Health Science Hiroshima University  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