{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T03:34:23Z","timestamp":1791516863725,"version":"4.3.4"},"reference-count":41,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Aim<\/jats:title><jats:sec><jats:label\/><jats:p>Portopulmonary hypertension (PoPH) is a well\u2010known complication of liver cirrhosis. The aim of this study was to clarify the pulmonary hemodynamics and the prevalence and characteristics of PoPH in patients with portal hypertension.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The subjects were 335 patients with portal hypertension diagnosed by hepatic vein pressure gradient (HVPG). Among them, 186 patients received measurements of pulmonary artery pressure (PAP), pulmonary artery wedge pressure (PAWP) and pulmonary vascular resistance (PVR). PoPH was diagnosed by PAP &gt;20\u00a0mmHg, PVR \u22653 Wood units (WU) and PAWP \u226415\u00a0mmHg.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The Child\u2013Pugh classification was class A in 53, B in 92 and C in 41 patients. Median (range) values of HVPG, PAP, PVR and PAWP were 18.4 (5.5\u201339.0) mmHg, 12.9 (6.6\u201340.8) mmHg, 0.8 (0.1\u20134.5) WU and 7.5 (2.2\u201315.4) mmHg, respectively. Of six patients with PAP &gt;20\u00a0mmHg, four had autoimmune hepatitis or primary biliary cholangitis, with the prevalence being significantly higher than that in patients with PAP \u226420\u00a0mmHg. Meanwhile, no significant difference was noted in the hepatic functional reserve or HVPG between patients with PAP &gt;20\u00a0mmHg and \u226420\u00a0mmHg. Only two patients met the diagnostic criteria of PoPH and both patients were Child\u2013Pugh B. The Child\u2013Pugh score and HVPG were not associated with PoPH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study demonstrated that only two patients were complicated by PoPH. High PAP values were noted in patients with primary biliary cholangitis or autoimmune hepatitis. However, the presence of PoPH and high PAP were not associated with the degree of hepatic functional reserve or HVPG.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.13560","type":"journal-article","created":{"date-parts":[[2020,8,21]],"date-time":"2020-08-21T17:56:13Z","timestamp":1598032573000},"page":"1244-1254","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Prevalence and characteristics of portopulmonary hypertension in cirrhotic patients who underwent both hepatic vein and pulmonary artery catheterization"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3374-7111","authenticated-orcid":false,"given":"Masanori","family":"Atsukawa","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology Nippon Medical School  1\u20101\u20105, Sendagi, Bunkyo\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihito","family":"Tsubota","sequence":"additional","affiliation":[{"name":"Core Research Facilities The Jikei University School of Medicine  3\u20109\u201018, Nishishinbashi, Minato\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaru","family":"Hatano","sequence":"additional","affiliation":[{"name":"Department of therapeutic strategy for heart failure The University of Tokyo  7\u20103\u20101, Hongo, Bunkyo\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chisa","family":"Kondo","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Nippon Medical School  1\u20101\u20105, Sendagi, Bunkyo\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaori","family":"Shioda","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Nippon Medical School  1\u20101\u20105, Sendagi, Bunkyo\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Ohno","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Nippon Medical School  1\u20101\u20105, Sendagi, Bunkyo\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadamichi","family":"Kawano","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Nippon Medical School  1\u20101\u20105, Sendagi, Bunkyo\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Korenobu","family":"Hayama","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Nippon Medical School  1\u20101\u20105, Sendagi, Bunkyo\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taeang","family":"Arai","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Nippon Medical School  1\u20101\u20105, Sendagi, Bunkyo\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ai","family":"Nakagawa\u2010Iwashita","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Nippon Medical School  1\u20101\u20105, Sendagi, Bunkyo\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norio","family":"Itokawa","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Nippon Medical School  1\u20101\u20105, Sendagi, Bunkyo\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiko","family":"Kaneko","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Nippon Medical School  1\u20101\u20105, Sendagi, Bunkyo\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Nippon Medical School Chiba Hokusoh Hospital  1715, kamakari, Inzai Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai","family":"Koeda","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Nippon Medical School Chiba Hokusoh Hospital  1715, kamakari, Inzai Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomomi","family":"Okubo","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Nippon Medical School Chiba Hokusoh Hospital  1715, kamakari, Inzai Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teppei","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Nippon Medical School Chiba Hokusoh Hospital  1715, kamakari, Inzai Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine Nippon Medical School  1\u20101\u20105, Sendagi, Bunkyo\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhiko","family":"Taniai","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal and Hepato\u2010Biliary\u2010Pancreatic Surgery Nippon Medical School  1\u20101\u20105, Sendagi, Bunkyo\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal and Hepato\u2010Biliary\u2010Pancreatic Surgery Nippon Medical School  1\u20101\u20105, Sendagi, Bunkyo\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidenori","family":"Kanazawa","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Nippon Medical School  1\u20101\u20105, Sendagi, Bunkyo\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wataru","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine Nippon Medical School  1\u20101\u20105, Sendagi, Bunkyo\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuhiko","family":"Iwakiri","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Nippon Medical School  1\u20101\u20105, Sendagi, Bunkyo\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"1310","article-title":"Diagnosis, prevention and treatment of hepatorenal syndrome in cirrhosis","volume":"56","author":"Salerno F","year":"2007","journal-title":"Gut"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.98.11051153"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000001229"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.04.00010904"},{"key":"e_1_2_7_6_1","first-page":"9629570","article-title":"Prevalence and Prognosis of Portopulmonary Hypertension in 223 Liver Transplant Recipients","volume":"18","author":"Li J","year":"2018","journal-title":"Can Respir J"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-0160"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200809-1472OC"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv317"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.04.011"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.10.029"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(91)90225-A"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200510-1668OC"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2008.02384.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1209655"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00032407"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.06.00030206"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199702270-00020"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00117511"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.21310"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.112.4.980"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21431"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01913-2018"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20062"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510250145"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.5935\/0103-507X.20190073"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.1909"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800600817"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.57.9151"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1159\/000479984"},{"key":"e_1_2_7_31_1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0889-8553(21)00177-1","article-title":"Methods to evaluate portal hypertension","volume":"21","author":"Lebrec D","year":"1992","journal-title":"Gastroenterol Clin North Am"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28990"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200804-613OC"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00145608"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22275"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.13545"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.12930"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2006.01701.x"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0b013e32835c504b"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199802270-00001"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1053\/jlts.2000.6356"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.07.061"}],"container-title":["Hepatology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hepr.13560","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/hepr.13560","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hepr.13560","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T10:20:58Z","timestamp":1693822858000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hepr.13560"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":41,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["10.1111\/hepr.13560"],"URL":"https:\/\/doi.org\/10.1111\/hepr.13560","archive":["Portico"],"relation":{},"ISSN":["1386-6346","1872-034X"],"issn-type":[{"value":"1386-6346","type":"print"},{"value":"1872-034X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"2020-07-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}