{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:11:58Z","timestamp":1747185118708,"version":"3.40.5"},"reference-count":21,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T00:00:00Z","timestamp":1599696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Esophageal variceal ligation (EVL) is usually carried out to decrease the risk of hemorrhage. Several complications have been reported with the procedure, including bleeding from ligation\u2010induced esophageal ulcers or heartburn. However, there is scant evidence for gastroesophageal reflux caused by EVL. The aim of this study was to assess 24\u2010h pH monitoring in the esophagogastric junction before and after EVL and the bleeding rate for 18\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We undertook this single\u2010center prospective trial in Kitasato University Hospital (Sagamihara, Japan). We included patients with cirrhosis who were Child\u2013Pugh classification A or B, without uncontrollable hepatocellular carcinoma, and had F2 or larger esophageal varices, and\/or were red color sign (RC) positive. The study period was from July 2012 through September 2017 for 32 patients enrolled in this study and followed up until March 2019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Baseline characteristics were: median Child\u2013Pugh score, 6; and mean age, 64.3\u00a0years. Before and after EVL, the median 24\u2010h under pH\u00a04 holding time percentages of all patients were 0.6% (range, 0\u20135.6%) and 0.95% (range, 0\u201350.6%), respectively, without a significant difference (<jats:italic>P<\/jats:italic>\u2009=\u20090.107). We could not find any G3 or G4 adverse events during this study, and 75% of the patients who had already suffered from moderate gastroesophageal reflux became worse after EVL (<jats:italic>P<\/jats:italic>\u2009=\u20090.18) and required antacid therapies. There were no patients with hemorrhage from esophageal varices.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Esophageal variceal ligation for esophageal varices did not significantly change gastroesophageal reflux. Therefore, acid suppressive therapy might be unnecessary for patients who do not suffer from gastroesophageal reflux after EVL.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.13562","type":"journal-article","created":{"date-parts":[[2020,8,25]],"date-time":"2020-08-25T06:12:05Z","timestamp":1598335925000},"page":"1255-1263","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Long\u2010term observation in patients with esophageal varices after endoscopic variceal ligation accompanied with 24\u2010hour pH monitoring"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4151-5663","authenticated-orcid":false,"given":"Hisashi","family":"Hidaka","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Internal Medicine Kitasato University School of Medicine  Sagamihara 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Second Hospital Jilin University  Changchun China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuichiro","family":"Iwasaki","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Internal Medicine Kitasato University School of Medicine  Sagamihara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naohisa","family":"Wada","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Internal Medicine Kitasato University School of Medicine  Sagamihara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kousuke","family":"Kubota","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Internal Medicine Kitasato University School of Medicine  Sagamihara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiaki","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Internal Medicine Kitasato University School of Medicine  Sagamihara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahide","family":"Nakazawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Internal Medicine Kitasato University School of Medicine  Sagamihara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1376-6051","authenticated-orcid":false,"given":"Akitaka","family":"Shibuya","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Internal Medicine Kitasato University School of Medicine  Sagamihara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigehiro","family":"Kokubu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Shin\u2010yurigaoka General Hospital  Kawasaki 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