{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T23:45:59Z","timestamp":1780703159876,"version":"3.54.1"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,3,16]],"date-time":"2021-03-16T00:00:00Z","timestamp":1615852800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Fibrosis regression has been observed in patients with chronic hepatitis C virus (HCV) infection treated with direct\u2010acting antivirals. This study was aimed at evaluating dynamic changes of serum Mac\u20102\u2010binding protein glycosylation isomer (M2BPGi) in patients with HCV genotype 1 receiving elbasvir\/grazoprevir.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>M2BPGi were serially measured at baseline, during and after therapy. Its diagnostic performance at baseline and sustained virological response at 24\u00a0weeks after treatment (SVR24) were compared with transient elastography (TE) and the aspartate aminotransferase\/platelet ratio index (APRI) using magnetic resonance elastography (MRE) as a reference.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 60 HCV mono\u2010infected and 36 HCV\/HIV co\u2010infected patients were included with SVR24 rates of 93.3% and 97.2%, respectively. At baseline, TE, M2BPGi and APRI were correlated with MRE (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.788, <jats:italic>r<\/jats:italic>\u00a0=\u00a00.703 and <jats:italic>r<\/jats:italic>\u00a0=\u00a00.564, respectively, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). The area under the receiver operator characteristics curves for TE, M2BPGi and APRI in differentiating significant fibrosis were 0.88 (95% confidence interval; 0.81\u20130.95, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001), 0.86 (0.79\u20130.94, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) and 0.74 (0.64\u20130.83, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001), respectively. The corresponding figures for cirrhosis were 0.95 (0.90\u20131.00, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001), 0.96 (0.92\u20131.00, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) and 0.88 (0.79\u20130.97, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001), respectively. Compared with baseline, all fibrosis markers significantly declined after achieving SVR24. The correlations of TE, M2BPGi and APRI with MRE at time of SVR24 were <jats:italic>r<\/jats:italic>\u00a0=\u00a00.587 (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001), <jats:italic>r<\/jats:italic>\u00a0=\u00a00.457 (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) and <jats:italic>r<\/jats:italic>\u00a0=\u00a00.293 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.004), respectively. In multivariate analysis, high baseline alanine aminotransferase level, HCV mono\u2010infection and advanced fibrosis were factors associated with M2BPGi reduction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>HCV eradication is associated with liver fibrosis improvement. M2BPGi has a better performance than APRI in monitoring liver fibrosis in patients treated with direct\u2010acting antivirals. This marker is applicable in resource\u2010limited settings where imaging\u2010based modalities are not widely accessible.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.13630","type":"journal-article","created":{"date-parts":[[2021,2,22]],"date-time":"2021-02-22T04:25:17Z","timestamp":1613967917000},"page":"528-537","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Liver fibrosis improvement assessed by magnetic resonance elastography and Mac\u20102\u2010binding protein glycosylation isomer\u00a0in patients with hepatitis C virus infection receiving direct\u2010acting antivirals"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5415-510X","authenticated-orcid":false,"given":"Natthaya","family":"Chuaypen","sequence":"first","affiliation":[{"name":"Center of Excellence in Hepatitis and Liver Cancer Department of Biochemistry Faculty of Medicine Chulalongkorn University  Bangkok 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