{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T15:08:51Z","timestamp":1783350531985,"version":"3.54.6"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,3,29]],"date-time":"2021-03-29T00:00:00Z","timestamp":1616976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Hepatic arterial infusion chemotherapy (HAIC) with cisplatin is beneficial to patients with advanced hepatocellular carcinoma (HCC) treated with sorafenib. This study aimed to examine the effect of HAIC with cisplatin before radiofrequency ablation (RFA) in patients with HCC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a multicenter, single\u2010blinded, randomized controlled study (UMIN000007267). Early\u2010stage HCC patients were randomly assigned (1:1) to receive HAIC with cisplatin before RFA therapy (HAIC group) or RFA monotherapy (non\u2010HAIC group). The primary end\u2010point was recurrence\u2010free survival. Efficacy analysis and safety analysis followed the intention\u2010to\u2010treat principle.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Between August 2012 and July 2016, 74 patients were recruited. A total of 70 eligible patients were randomly assigned to the HAIC group (<jats:italic>n<\/jats:italic>\u00a0=\u00a035) and non\u2010HAIC group (<jats:italic>n<\/jats:italic>\u00a0=\u00a035). Recurrence\u2010free survival rates at 1 (3)\u00a0year in the HAIC group and non\u2010HAIC group were 82.9% (54.3%) and 74.3% (34.3%), respectively (hazard ratio [HR], 0.597; 95% confidence interval [CI], 0.320\u20131.091; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.094]. Subgroup analysis showed that the beneficial effect of HAIC was observed in patients with a single nodule and Child\u2013Pugh score 5. Intrahepatic distant recurrence\u2010free survival rate in the HAIC group was significantly better than that in the non\u2010HAIC group (HR, 0.468; 95% CI, 0.235\u20130.896; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.022). Adverse events were observed in just two patients in the HAIC group (6%) \u2013 grade\u00a02 cholecystitis and grade\u00a02 hyperkalemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>HAIC with cisplatin before RFA did not significantly decrease recurrence in patients with early\u2010stage HCC. However, it might be effective in preventing intrahepatic distant recurrence.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.13633","type":"journal-article","created":{"date-parts":[[2021,3,9]],"date-time":"2021-03-09T10:32:24Z","timestamp":1615285944000},"page":"694-701","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Randomized controlled study to examine the efficacy of hepatic arterial infusion chemotherapy with cisplatin before radiofrequency ablation for hepatocellular carcinoma"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0562-9671","authenticated-orcid":false,"given":"Atsushi","family":"Oyama","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences  Okayama 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