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Proprotein convertase subtilisin\u2010kexin like\u20109 (PCSK9) plays an important role in regulating quantitative lipid levels. This study examined the interactions between quantitative PCSK9 and lipid changes, as well as qualitative lipid changes in terms of lectin\u2010like oxidized low\u2010density lipoprotein (LDL) receptor\u20101 ligand containing apolipoprotein\u00a0B (LAB) and high\u2010density lipoprotein (HDL) cholesterol uptake capacity (HDL\u2010CUC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with chronic HCV infection (<jats:italic>N<\/jats:italic>\u00a0=\u00a0231) who achieved an SVR by direct\u2010acting antivirals without lipid\u2010lowering therapy were included for comparisons of PCSK9, LAB, HDL\u2010CUC, and other clinical indices between pretreatment and SVR12 time points.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>LDL (LDL) cholesterol and HDL cholesterol levels were quantitatively increased at SVR12, along with higher PCSK9 (all <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001). PCSK9 was significantly correlated with LDL cholesterol (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.244, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.0003) and apolipoprotein\u00a0B (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.222, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.0009) at SVR12. Regarding qualitative LDL changes, LAB was significantly decreased and LAB\/LDL cholesterol and LAB\/apolipoprotein\u00a0B proportions were improved at SVR12 (all <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001). In terms of qualitative HDL changes, HDL\u2010CUC was significantly ameliorated, along with HDL\u2010CUC\/HDL cholesterol, HDL\u2010CUC\/ apolipoprotein\u00a0A1, and HDL\u2010CUC\/ apolipoprotein\u00a0A2 at SVR12 (all <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>HCV eradication by direct\u2010acting antivirals may produce quantitative lipid profile changes, along with PCSK9 production recovery in addition to qualitative lipid improvement, which possibly confers the additional secondary benefits of atherosclerosis improvement and cardiovascular disease event reduction.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.13666","type":"journal-article","created":{"date-parts":[[2021,5,13]],"date-time":"2021-05-13T08:48:17Z","timestamp":1620895697000},"page":"758-766","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Quantitative and 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