{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T09:22:47Z","timestamp":1783416167678,"version":"3.54.6"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,6,5]],"date-time":"2021-06-05T00:00:00Z","timestamp":1622851200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100011912","name":"Taipei Veterans General Hospital","doi-asserted-by":"publisher","award":["VN110\u201002"],"award-info":[{"award-number":["VN110\u201002"]}],"id":[{"id":"10.13039\/501100011912","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Liver functional reserve is a major prognostic determinant in patients with hepatocellular carcinoma (HCC). The albumin\u2013bilirubin (ALBI) score is an objective method to assess the severity of cirrhosis in this setting. However, calculation of the ALBI score is complex and difficult to access in clinical practice. Recently, the EZ (easy)\u2010ALBI score was proposed as an alternative biomarker of liver injury. We aimed to evaluate the prognostic role of the EZ\u2010ALBI score in HCC from early to advanced stages.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 3794 newly diagnosed HCC patients were prospectively enrolled and retrospectively analyzed. Independent prognostic predictors were determined by using the multivariate Cox proportional hazards model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The EZ\u2010ALBI score showed good correlation with the ALBI score (correlation coefficient, 0.965; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). The correlation of the EZ\u2010ALBI score was highly preserved in different Child\u2013Turcotte\u2013Pugh (CTP) classifications, treatment methods, and Barcelona Clinic Liver Cancer (BCLC) stages (correlation coefficients, 0.90\u20130.97). In the Cox multivariate analysis, age &gt;65\u00a0years, male sex, serum <jats:italic>\u03b1<\/jats:italic>\u2010fetoprotein &gt;20\u00a0ng\/ml, large or multiple tumors, total tumor volume &gt;100\u00a0cm<jats:sup>3<\/jats:sup>, vascular invasion or distant metastasis, ascites, poor performance status, EZ\u2010ALBI grade 2 and 3, and noncurative treatments were independently associated with increased mortality (all <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). Moreover, EZ\u2010ALBI grade can stratify long\u2010term survival in patients with different CTP class, treatment strategy, and BCLC stage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The EZ\u2010ALBI score is an easy and feasible method to evaluate liver functional reserve. As a new prognostic biomarker in HCC, the predictive power of the EZ\u2010ALBI grade is independent across different cancer stages and treatments.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.13671","type":"journal-article","created":{"date-parts":[[2021,5,26]],"date-time":"2021-05-26T13:01:54Z","timestamp":1622034114000},"page":"1129-1138","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Easy albumin\u2013bilirubin score as a new prognostic predictor in hepatocellular carcinoma"],"prefix":"10.1111","volume":"51","author":[{"given":"Shu\u2010Yein","family":"Ho","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology Min\u2010Sheng General Hospital  Taoyuan Taiwan, ROC"},{"name":"Department of Medical Research Taipei Veterans General Hospital  Taipei Taiwan, ROC"},{"name":"School of Medicine National Yang Ming Chiao Tung University  Taipei Taiwan, ROC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po\u2010Hong","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Medicine National Yang Ming Chiao Tung University  Taipei Taiwan, ROC"},{"name":"Department of Internal Medicine University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia\u2010Yang","family":"Hsu","sequence":"additional","affiliation":[{"name":"School of Medicine National Yang Ming Chiao Tung University  Taipei Taiwan, ROC"},{"name":"Division of Gastroenterology and Hepatology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih\u2010Chieh","family":"Ko","sequence":"additional","affiliation":[{"name":"School of Medicine National Yang Ming Chiao Tung University  Taipei Taiwan, ROC"},{"name":"Department of Medicine Taipei Veterans General Hospital  Taipei Taiwan, ROC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Hsiang","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Medicine National Yang Ming Chiao Tung University  Taipei Taiwan, ROC"},{"name":"Department of Medicine Taipei Veterans General Hospital  Taipei Taiwan, ROC"},{"name":"Institute of Clinical Medicine National Yang Ming Chiao Tung University  Taipei Taiwan, ROC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien\u2010Wei","family":"Su","sequence":"additional","affiliation":[{"name":"School of Medicine National Yang Ming Chiao Tung University  Taipei Taiwan, ROC"},{"name":"Department of Medicine Taipei Veterans General Hospital  Taipei Taiwan, ROC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng\u2010Yuan","family":"Hsia","sequence":"additional","affiliation":[{"name":"School of Medicine National Yang Ming Chiao Tung University  Taipei Taiwan, ROC"},{"name":"Department of Surgery Taipei Veterans General Hospital  Taipei Taiwan, ROC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping\u2010Hsing","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Medical Research Taipei Veterans General Hospital  Taipei Taiwan, ROC"},{"name":"Institute of Pharmacology National Yang Ming Chiao Tung University  Taipei Taiwan, ROC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih\u2010Jie","family":"Chou","sequence":"additional","affiliation":[{"name":"Department of Medical Research Taipei Veterans General Hospital  Taipei Taiwan, ROC"},{"name":"Institute of Pharmacology National Yang Ming Chiao Tung University  Taipei Taiwan, ROC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rheun\u2010Chuan","family":"Lee","sequence":"additional","affiliation":[{"name":"School of Medicine National Yang Ming Chiao Tung University  Taipei Taiwan, ROC"},{"name":"Department of Radiology Taipei Veterans General Hospital  Taipei Taiwan, ROC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010Chih","family":"Hou","sequence":"additional","affiliation":[{"name":"School of Medicine National Yang Ming Chiao Tung University  Taipei Taiwan, ROC"},{"name":"Department of Medicine Taipei Veterans General Hospital  Taipei Taiwan, ROC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2202-521X","authenticated-orcid":false,"given":"Teh\u2010Ia","family":"Huo","sequence":"additional","affiliation":[{"name":"Department of Medical Research Taipei Veterans General Hospital  Taipei Taiwan, ROC"},{"name":"School of Medicine National Yang Ming Chiao Tung University  Taipei Taiwan, ROC"},{"name":"Institute of Pharmacology National Yang Ming Chiao Tung University  Taipei Taiwan, 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