{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T19:48:34Z","timestamp":1789069714153,"version":"build-2803163510"},"reference-count":43,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,8,17]],"date-time":"2021-08-17T00:00:00Z","timestamp":1629158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Non\u2010malignant portal vein thrombosis (PVT) is a complication of liver cirrhosis. The aim of this study was to evaluate the annual incidence of PVT and related risk factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively reviewed clinical, laboratory, and radiological data collected prospectively from September 2016 to September 2017. A follow\u2010up of 36\u00a0months was performed in a subset of patients to determine the cumulative incidence of PVT and related complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study included 567 patients. The incidence of PVT at 12, 24, and 36\u00a0months was 3.7%, 0.8%, and 1.4%, respectively. Patients with PVT were compared with patients without PVT, and showed differences in albumin (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.04), aspartate aminotransferase (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.04), hemoglobin (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.01), and prothrombin activity (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.01). The presence of hydropic decompensation (57.1% vs. 30.1%; <jats:italic>p<\/jats:italic> 0.004), gastroesophageal varices (76.2% vs. 39.5%; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.05), variceal bleeding (52.4% vs. 22.7%; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001), hepatic encephalopathy (38.1% vs. 9.9%; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.01), spontaneous bacterial peritonitis (9.5% vs. 1.7%; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001), and use of beta\u2010blockers (71.4% vs. 27.7%; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) were significantly associated. In the multivariate analysis, use of beta\u2010blockers and hepatic encephalopathy appeared as risk factors, and high albumin levels a protective factor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The incidence of PVT was 3.7%. Beta\u2010blockers and hepatic encephalopathy were risks factors. High albumin levels were a protective factor.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.13703","type":"journal-article","created":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T17:59:48Z","timestamp":1627581588000},"page":"1064-1072","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Non\u2010malignant portal vein thrombosis in a cohort of cirrhotic patients: Incidence and risk factors"],"prefix":"10.1111","volume":"51","author":[{"given":"Marta","family":"Lopez\u2010Gomez","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Hospital Universitario Puerta de Hierro  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elba","family":"Llop","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Hospital Universitario Puerta de Hierro  Madrid 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Valdecilla  Santander Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Luis","family":"Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Hospital Universitario Puerta de Hierro  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Abad","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Hospital Universitario Puerta de Hierro  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Hospital Universitario Puerta de Hierro  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christie","family":"Perell\u00f3","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Hospital Universitario Puerta de Hierro  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