{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T08:11:37Z","timestamp":1787991097790,"version":"build-2784847793"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,11,6]],"date-time":"2021-11-06T00:00:00Z","timestamp":1636156800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Long\u2010term use of nucleotide analogs such as adefovir (ADV) or tenofovir disoproxil fumarate (TDF) may cause renal impairment. Tenofovir alafenamide (TAF) has less systemic exposure than TDF did. The aims were to examine longitudinal changes in renal function and biochemical parameters for 2\u00a0years after switching from long\u2010term ADV and TDF to TAF, and to explore factors associated with improved renal function after TAF in patients with chronic hepatitis B.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The prospective observational cohort study included 306 patients with chronic hepatitis B who underwent switching from long\u2010term TDF or ADV to TAF. The primary outcome was the changes in estimated glomerular filtration rate (eGFR) after TAF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 306 patients, 190 (65.3%) and 106 (34.7%) had chronic kidney disease (CKD) stages 1\u20132 and 3a\u20134 at baseline. In patients with CKD stages 3a\u20134, the mean eGFR significantly increased until week 12 and plateaued from week 12 to year 2 (adjusted slope using linear mixed effect models: +9.01\u00a0ml\/min\/1.73\u00a0m<jats:sup>2<\/jats:sup>\/year until week 12; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). In contrast, the mean eGFR plateaued from baseline to year 2 in the CKD stages 1\u20132 subgroup. Multivariate logistic regression showed that baseline CKD stage \u22653a, steeper decline in eGFR 1\u00a0year before TAF, and shorter duration of any nucleotide analog use was significantly associated with \u226510% improvement in eGFR in year 1.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Switching from TDF or ADV to TAF resulted in favorable renal safety for 2\u00a0years. In CKD stage 3a\u20134 subgroup, eGFR after TAF was recovered in the first 12\u00a0weeks and subsequently stabilized.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.13726","type":"journal-article","created":{"date-parts":[[2021,10,23]],"date-time":"2021-10-23T06:16:58Z","timestamp":1634969818000},"page":"153-164","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Renal safety and biochemical changes for 2\u00a0years after switching to tenofovir alafenamide from long\u2010term other nucleotide analog treatment in patients with chronic hepatitis B"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0302-2275","authenticated-orcid":false,"given":"Tetsuya","family":"Hosaka","sequence":"first","affiliation":[{"name":"Department of Hepatology Toranomon Hospital  Tokyo 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