{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T23:39:42Z","timestamp":1767829182739,"version":"3.49.0"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,12,8]],"date-time":"2021-12-08T00:00:00Z","timestamp":1638921600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study aimed to demonstrate the feasibility of identifying candidates of portopulmonary hypertension (PoPH) from general portal hypertension patients based on chest computed tomography (CT) results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred and thirty patients with portal hypertension who had undergone interventional radiology therapies at our hospital between August 2011 and July 2021 were included, and preoperative clinical data were collected. Suspicious PoPH was defined as main pulmonary artery diameter (mPA\u2010D)\u00a0\u2265\u00a029\u00a0mm or the ratio of mPA\u2010D to ascending aorta diameter (mPA\u2010D\/aAo\u2010D)\u00a0\u2265\u00a01.0, and probable PoPH as mPA\u2010D\u00a0\u2265\u00a033\u00a0mm based on the chest CT. Prevalence of suspicious and probable PoPH was evaluated, and the differences in clinical characteristics of each population were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 29 (22.3%) and 5 (3.8%) patients were categorized as suspicious and probable PoPH, respectively. Univariate analyses revealed that female sex, higher shortest diameter of inferior vena cava, presence of portosystemic shunts \u2265\u00a05\u00a0mm, and lower blood urea nitrogen levels were significantly associated with suspicious PoPH (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). Multivariate analyses identified all four factors as significantly independent determinants of suspicious PoPH (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). In addition, among the population of suspicious PoPH, there were significant differences in seven parameters, including total bilirubin levels and spleen volume between patients with and without probable PoPH (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). However, no significant independent indicators of probable PoPH were found.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>CT\u2010based measurements of mPA\u2010D and mPA\u2010D\/aAo\u2010D have the potential to screen patients with suspicious PoPH in clinical practice focused on portal hypertension.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.13735","type":"journal-article","created":{"date-parts":[[2021,11,25]],"date-time":"2021-11-25T17:25:28Z","timestamp":1637861128000},"page":"255-268","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Screening for portopulmonary hypertension using computed tomography\u2010based measurements of the main pulmonary artery and ascending aorta diameters in patients with portal 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