{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T17:00:08Z","timestamp":1784221208735,"version":"3.55.0"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,2,5]],"date-time":"2022-02-05T00:00:00Z","timestamp":1644019200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The purpose of this study was to examine the effect of pemafibrate (PEM) in primary biliary cholangitis (PBC) patients with dyslipidemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients who were diagnosed with PBC between June 2018 and December 31, 2020 were included in the study if they also had dyslipidemia and their alkaline phosphatase (ALP) or gamma\u2010glutamyl transferase (GGT) levels remained above the normal range despite taking 600\u00a0mg\/day ursodeoxycholic acid (UDCA) for at least 6\u00a0months. Patients who were treated with UDCA alone\u00a0were administered PEM as an add\u2010on (PEM\u2010add group), and patients who\u00a0were treated with UDCA and bezafibrate (BEZ) for at least 6\u00a0months were\u00a0given PEM instead of BEZ (PEM\u2010switch group). Clinical parameters were\u00a0compared in all patients, and the levels of ALP, GGT, the estimated glomerular filtration rate (eGFR), and creatinine (Cr) were compared between the\u00a0PEM\u2010add and PEM\u2010switch groups. Improvement in cholangitis was also evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the PEM\u2010add group, both ALP and GGT improved in 40 of 46 patients (87.0%). In the PEM\u2010switch group, both ALP and GGT improved in 15 of 29 patients (51.7%). In the PEM\u2010switch group, however, significant improvement was seen in eGFR and Cr.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Administration of PEM is effective in PBC patients with dyslipidemia who are refractory to UDCA monotherapy. In patients using both UDCA and BEZ, there was an advantage in switching to PEM if they had renal damage; however, improvement of ALP and GGT occurred in about 50%.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.13747","type":"journal-article","created":{"date-parts":[[2022,1,24]],"date-time":"2022-01-24T16:03:18Z","timestamp":1643040198000},"page":"522-531","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Effects of pemafibrate on primary biliary cholangitis with dyslipidemia"],"prefix":"10.1111","volume":"52","author":[{"given":"Mayumi","family":"Yamaguchi","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Dokkyo Medical University Saitama Medical Center Minami\u2010Koshigaya Koshigaya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeharu","family":"Asano","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Jichi Medical University Saitama 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