{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T08:36:04Z","timestamp":1788942964393,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T00:00:00Z","timestamp":1644364800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The present study focused on the association of early bevacizumab (Bev) interruption with the clinical outcome of atezolizumab plus bevacizumab.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study included 239 patients with advanced hepatocellular carcinoma receiving atezolizumab\/Bev from September 2020 to June 2021 at 16 different institutions in Japan. We conducted a 9\u2010week landmark analysis to investigate the association of Bev interruption due to adverse events with the therapeutic efficacy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median age was 73.0 (68.0\u201380.0) years old, with 195 (81.6%) men. The objective response rate was significantly higher in patients without Bev interruption than in those with it (34.5% vs. 17.3%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.038). The median progression\u2010free survival (PFS) was 6.5\u00a0months (95% confidence interval [CI] 4.5\u20139.7) and 9.0\u00a0months (95% CI 7.1\u2013not applicable) in patients with and without Bev interruption, respectively, with statistical significance (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.021). The 12\u2010month overall survival (OS) rates in patients with and without Bev interruption were 49.4% (CI 27.7%\u201367.9%) and 82.2% (95% CI 70.3%\u201389.6%), respectively, showing a significant difference (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.004). The presence of Bev interruption was a significant factor associated with the PFS (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.021) and OS (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.008). A multivariate analysis showed that modified albumin\u2013bilirubin 2b (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) and later\u2010line treatment (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.018) were unfavorable factors associated with Bev interruption. Liver injury, appetite loss, protein urea, and ascites or hepatic edema were more frequently found in patients with Bev interruption than in those without it.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Early Bev interruption was an unfavorable factor associated with the PFS and OS. Good liver function and treatment settings may be associated with maintaining Bev treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.13748","type":"journal-article","created":{"date-parts":[[2022,1,26]],"date-time":"2022-01-26T05:08:16Z","timestamp":1643173696000},"page":"462-470","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Association of early bevacizumab interruption with efficacy of atezolizumab plus bevacizumab for advanced hepatocellular carcinoma: A landmark analysis"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3656-285X","authenticated-orcid":false,"given":"Takeshi","family":"Hatanaka","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Gunma Saiseikai Maebashi Hospital  Maebashi 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