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We then analyzed and summarized these articles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found that HBV related biomarkers maybe could predict NAs withdrawal safely and the possibility of relapse after treatment cessation, including hepatitis B e antigen (HBeAg), hepatitis B surface antigen (HBsAg), HBV DNA, HBV RNA, pregenomic\u2010RNA (pgRNA), hepatitis B core\u2010related antigen (HBcrAg), hepatitis B core antibody (anti\u2010HBc), and models containing several indicators for predicting the effectiveness of treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>HBV DNA, HBV RNA, pgRNA, HBcrAg, anti\u2010HBc, as well as the prediction models formed by several biomarkers could predict the safe discontinuation of NAs before HBsAg loss and recurrence.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.13749","type":"journal-article","created":{"date-parts":[[2022,1,28]],"date-time":"2022-01-28T14:04:25Z","timestamp":1643378665000},"page":"337-351","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Biomarkers for predicting nucleos(t)ide analogs discontinuation and hepatitis B virus recurrence after drug withdrawal in chronic hepatitis B patients"],"prefix":"10.1111","volume":"52","author":[{"given":"Mengqi","family":"Luo","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases and Hepatology Unit State Key Laboratory of Organ Failure Research Guangdong Key Laboratory of Viral Hepatitis Research Institutes of Liver Diseases Research of Guangdong Province Nanfang Hospital Southern Medical University  Guangzhou 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and Hepatology Unit State Key Laboratory of Organ Failure Research Guangdong Key Laboratory of Viral Hepatitis Research Institutes of Liver Diseases Research of Guangdong Province Nanfang Hospital Southern Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,2,21]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(18)30056-6"},{"key":"e_1_2_12_3_1","article-title":"EASL\u2010AASLD HBV treatment endpoints Conference FacultyGuidance for design and endpoints of clinical trials in chronic hepatitis B \u2010 report from the 2019 EASL\u2010AASLD HBV treatment endpoints Conference","author":"Cornberg 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